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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Community-acquired infectious diarrhoea in children under 5 years of age in Dakar, Senegal
Paediatrics and International Child Health, Volume 33, No. 3, Year 2013
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Description
Background: In sub-Saharan Africa, infectious diarrhoea is a major cause of childhood morbidity and mortality. A cross-sectional study was undertaken to document the pathogens potentially involved in community-acquired childhood diarrhoea in Dakar, the capital of Senegal. Methods: Between September 2007 and March 2008, 176 children aged 1 month to 5 years were recruited consecutively from a primary health care institution in an urban area. Clinical data were recorded and stool samples were collected. Bacterial pathogens were identified using conventional methods and/or PCR assays. Rotaviruses and adenoviruses were detected by a rapid immunochromatographic test. Intestinal parasites were diagnosed by microscopy. Results: Rotavirus was the most common enteric pathogen, detected in 27% of patients, followed by Shigella (12%), diarrhoeagenic Escherichia coli (8%), enteric adenovirus (8%), Salmonella (4%), Campylobacter jejuni (3%) and Plesiomonas shigelloides (2%). Mixed bacterial/viral infections were detected in 6% of cases. Parasites, mostly protozoa, were detected in 14% of children. Using ipaH PCR, 30% of samples were positive for Shigella/entero-invasive E. coli. Detection of rotavirus was more frequently associated with younger age groups (<24 months), whereas bacterial diarrhoea was isolated more often in children over 1 year of age. Detection of bacterial pathogens was significantly associated with malnutrition. Antibiotics were prescribed for 77% of children who attended for consultation. No pathogen was found in 36% of them, whereas a virus was detected without any other associated bacterial or parasitic pathogen in 23% of patients. Conclusion: In developing countries, there is a need to develop reliable, easy-to-use, inexpensive rapid diagnostic tests to guide the management of diarrhoea in infants and children and thereby prevent over-use of antimicrobial agents. © W. S. Maney & Son Ltd 2013.
Authors & Co-Authors
Sire, Jean Marie
France, Poissy
Centre Hospitalier Intercommunal Poissy-st-germain-en-laye
Senegal, Dakar
Institut Pasteur de Dakar
Garin, Benoît
Senegal, Dakar
Institut Pasteur de Dakar
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Chartier, Loïc
France, Paris
Institut Pasteur, Paris
Fall, Ndèye Maguette
Senegal, Dakar
Institut Pasteur de Dakar
Tall, Adama
Senegal, Dakar
Institut Pasteur de Dakar
Seck, Abdoulaye
Senegal, Dakar
Institut Pasteur de Dakar
Weill, François Xavier
France, Paris
Institut Pasteur, Paris
Breurec, Sébastien
Senegal, Dakar
Institut Pasteur de Dakar
Vray, Muriel M.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 38
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1179/2046905512Y.0000000046
ISSN:
20469047
e-ISSN:
20469055
Research Areas
Food Security
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Senegal