Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Triple-negative breast cancer: Distinguishing between basal and nonbasal subtypes
Clinical Cancer Research, Volume 15, No. 7, Year 2009
Notification
URL copied to clipboard!
Description
Purpose: Triple-negative (TN; estrogen receptor, progesterone receptor, and HER-2 negative) cancer and basal-like breast cancer (BLBC) are associated with poor outcome and lack the benefit of targeted therapy. It is widely perceived that BLBC and TN tumors are synonymous and BLBC can be defined using a TN definition without the need for the expression of basal markers. Experimental Design: We have used two well-defined cohorts of breast cancers with a large panel of biomarkers, BRCA1 mutation status, and follow-up data to compare the clinico- pathologic and immunohistochemical features of TN tumors expressing one or more of the specific basal markers (CK5/6, CK17, CK14, and epidermal growth factor receptor; BLBC) with those TN tumors that express none of these markers (TN3BKE-). Results: Here, we show that although the morphologic features of BLBC are not significantly different from that of TN3BKE-tumors, BLBC showed distinct clinical and immunophenotypic differences. BLBC showed a statistically significant association with the expression of the hypoxia-associated factor (CA9), neuroendocrine markers, and other markers of poor prognosis such as p53. A difference in the expression of cell cycle-associated proteins and biomarkers involved in the immunologic portrait of tumors was seen. Compared with TN3BKE-tumors, BLBC was positively associated with BRCA1 mutation status and showed a unique pattern of distant metastasis, better response to chemotherapy, and shorter survival. Conclusion: TN breast cancers encompass a remarkably heterogeneous group of tumors. Expression of basal markers identifies a biologically and clinically distinct subgroup of TN tumors, justifying the use of basal markers (inTN tumors) to define BLBC. © 2009 American Association for Cancer Research.
Authors & Co-Authors
Rakha, Emad A.
United Kingdom, Nottingham
University of Nottingham
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Elsheikh, Somaia Elbauomy
United Kingdom, Nottingham
University of Nottingham
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Aleskandarany, Mohammed A.
United Kingdom, Nottingham
University of Nottingham
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Habashi, Hany O.
United Kingdom, Nottingham
University of Nottingham
Egypt, Mansoura
Mansoura University
Green, Andew R.
United Kingdom, Nottingham
University of Nottingham
Powe, Desmond George
United Kingdom, Nottingham
University of Nottingham
El-Sayed, Maysa E.
United Kingdom, Nottingham
University of Nottingham
Benhasouna, Ahmed A.
United Kingdom, Nottingham
University of Nottingham
Brunet, Jean Sébastien
Canada, Montreal
Université Mcgill
Canada, Montreal
Pharsight Corporation, Canada
Akslen, Lars Andreas
Norway, Bergen
Universitetet I Bergen
Evans, Andrew J.
United Kingdom, Nottingham
University of Nottingham
Blamey, Roger W.
United Kingdom, Nottingham
University of Nottingham
Reis-Filho, Jorge Sérgio
United Kingdom, London
The Institute of Cancer Research
Foulkes, William D.
Canada, Montreal
Université Mcgill
Ellis, Ian O.
United Kingdom, Nottingham
University of Nottingham
Statistics
Citations: 482
Authors: 15
Affiliations: 7
Identifiers
Doi:
10.1158/1078-0432.CCR-08-2132
ISSN:
10780432
Research Areas
Cancer
Study Design
Cohort Study