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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice
Toxicon, Volume 47, No. 5, Year 2006
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Description
Hydrated sodium calcium aluminosilicate (HSCAS), an anticaking agent for mixed feed, was added alone or simultaneously with a toxic Zearalenone (ZEN) dose to balb/c mice and was evaluated for its ability to restore damages induced by ZEN. The latter is a mycotoxin produced by fusarium genera; it is mainly known to induce several toxic effects such as hepatotoxicity, immunotoxicity and nephrotoxicity on animals and humans. The experimental approach consisted of eight treatments of six mice each by 400 mg/kg bw or 5 g/kg bw of HSCAS. Two experimental groups have received respectively ZEN alone at 40 (8% of LD50) and at 500 mg/kg bw (LD50). Two other groups have received ZEN at 40 or 500 mg/kg bw combined respectively with HSCAS at 400 mg/kg bw and 5 g/kg bw. The control groups received water or olive oil. Forty-eight hours after treatment, blood samples were collected for haematological and serum biochemical parameters measurements. ZEN treatment significantly increased hematocrit, haemoglobin, white blood cells: lymphocytes, eosinophils, neutrophils, monocytes and the most of biochemical serum parameters; it significantly reduced platelets and induced degenerative changes in the hepatic and renal tissues; while, the mixture of HSCAS with ZEN induced a reestablishment of haematological parameters, levels of serum biochemical enzyme activities and histological pictures of both liver and kidney. It also prevented general toxicity of ZEN. This was observed by the shift of LD50 for this toxin. Thus, our data strongly suggested that deleterious effects of ZEN could be overcome or, at least, significantly were diminished by HSCAS. Moreover, this sorbent by itself did not show any toxic effects. © 2006 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Abbès, Samir
Tunisia, Tunis
University of Carthage
Ouanes, Zouhour
Tunisia, Monastir
Faculty of Dentistry
Ben Salah-Abbès, Jalila Ben
Tunisia, Tunis
University of Carthage
Haouas, Zohra
Tunisia, Monastir
Faculté de Médecine de Monastir
Oueslati, Ridha
Tunisia, Tunis
University of Carthage
Bacha, Hassen
Tunisia, Monastir
Faculty of Dentistry
Othman, Omar
Tunisia, Tunis
University of Carthage
Statistics
Citations: 155
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.toxicon.2006.01.016
ISSN:
00410101
Research Areas
Environmental