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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Quantiferon®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting
PLoS ONE, Volume 7, No. 7, Article e37851, Year 2012
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Description
Aim: To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania. Methods: Sensitivity and specificity of QFT and TST for diagnosing active TB as well as indeterminate QFT rates and IFN-γ levels were assessed in 211 TB suspect children in a Tanzanian district hospital and contrasted in 90 adults with confirmed pulmonary TB. Results: Sensitivity of QFT and TST in children with confirmed TB was 19% (5/27) and 6% (2/31) respectively. In adults sensitivity of QFT and TST was 84% (73/87) and 85% (63/74). The QFT indeterminate rate in children and adults was 27% and 3%. Median levels of IFN-γ were lower in children than adults, particularly children <2 years and HIV infected. An indeterminate result was associated with age <2 years but not malnutrition or HIV status. Overall childhood mortality was 19% and associated with an indeterminate QFT result at baseline. Conclusion: QFT and TST showed poor performance and a surprisingly low sensitivity in children. In contrast the performance in Tanzanian adults was good and comparable to performance in high-income countries. Indeterminate results in children were associated with young age and increased mortality. Neither test can be recommended for diagnosing active TB in children with immature or impaired immunity in a high-burden setting. © 2012 Rose et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3395691/bin/pone.0037851.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3395691/bin/pone.0037851.s002.doc
Authors & Co-Authors
Rose, Michala Vaaben
Denmark, Copenhagen
Københavns Universitet
Denmark, Hvidovre
Hvidovre Hospital
Kimaro, Godfather Dickson
Tanzania, Tanga
National Institute for Medical Research Tanga
Nissen, Thomas Nørrelykke
Denmark, Hvidovre
Hvidovre Hospital
Kroidl, Inge
Tanzania
Nimr-mbeya Medical Research Programme
Germany, Munich
Klinikum Der Universität München
Höelscher, Michael
Germany, Munich
Klinikum Der Universität München
Bygbjerg, Ib Christian
Denmark, Copenhagen
Københavns Universitet
Mfinanga, Sayoki Godfrey Mrinde
Tanzania, Tanga
National Institute for Medical Research Tanga
Ravn, Pernille
Denmark, Odense
Odense Universitetshospital
Statistics
Citations: 56
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0037851
e-ISSN:
19326203
Research Areas
Food Security
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Tanzania