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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cyclopia maculata and Cyclopia subternata (honeybush tea) inhibits adipogenesis in 3T3-L1 pre-adipocytes
Phytomedicine, Volume 20, No. 5, Year 2013
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Description
The stems, leaves and flowers of Cyclopia have been consumed as a herbal tea 'honeybush tea' to treat various medical ailments since the 19th century. Plant polyphenols are reported to inhibit adipogenesis in cell and animal models of obesity. The aim of this study was to assess the effect of hot water extracts of two Cyclopia species, C. maculata and C. subternata on obesity in an in vitro model. The total polyphenol content of unfermented C. subternata, unfermented C. maculata and fermented C. maculata extracts was 25.6, 22.4 and 10.8 g GAE/100 g, respectively. The major compounds present in the extracts were: the flavonoid, phloretin-3′,5′-di-C-glucoside in C. subternata, the xanthone, mangiferin in unfermented C. maculata and the flavanone, hesperidin in fermented C. maculata. All of the plant extracts inhibited intracellular triglyceride and fat accumulation, and decreased PPARγ2 expression. The higher concentrations of unfermented C. maculata (800 and 1600 μg/ml) and C. subternata (1600 μg/ml) were cytotoxic in terms of decreased mitochondrial dehydrogenase activity. Both fermented and unfermented C. maculata, at concentrations greater than 100 μg/ml, decreased cellular ATP content. Cyclopia maculata and C. subternata inhibit adipogenesis in vitro, suggesting their potential as anti-obesity agents. © 2013 Elsevier GmbH.
Authors & Co-Authors
Dudhia, Zulfaqar
South Africa, Tygerberg
South African Medical Research Council
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Louw, Johan A.
South Africa, Tygerberg
South African Medical Research Council
Muller, Christo John Frederick
South Africa, Tygerberg
South African Medical Research Council
Joubert, Elizabeth
South Africa, Pretoria
Agricultural Research Council, Pretoria
South Africa, Stellenbosch
Stellenbosch University
De Beer, Dalene
South Africa, Pretoria
Agricultural Research Council, Pretoria
Kinnear, Craig J.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
South Africa, Tygerberg
South African Medical Research Council
Pheiffer, Carmen
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 47
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.phymed.2012.12.002
ISSN:
09447113
e-ISSN:
1618095X
Research Areas
Environmental
Noncommunicable Diseases