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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HDL remodeling during the acute phase response
Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 29, No. 2, Year 2009
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Description
Objective - The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A2 (sPLA2-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after cardiac surgery. Methods and Results - Plasma was collected from patients before (pre-AP), 24 hours after (AP-1 d), and 5 days after cardiac surgery (AP-5 d). SAA levels were increased 16-fold in AP-1 d samples. The activity of sPLA2-IIA was increased from 77.7±38.3 U/mL (pre-AP) to 281.4±57.1 U/mL (AP-1 d; P<0.001). CETP mass and activity reduction was commensurate to the reduction of HDL cholesterol levels. The combined action of SAA, sPLA2-IIA, and CETP in vitro markedly remodeled HDL with the generation of lipid-poor apoA-I from both pre-AP and AP-1 d HDL. The net result of this remodeling was a relative preservation of ABCA1- and ABCG1-dependent cholesterol efflux during the acute phase response. Conclusions - Our results show that the many and complex changes in plasma proteins during the acute phase response markedly remodel HDL with functional implications, particularly the relative retention of cholesterol efflux capacity. © 2009 American Heart Association, Inc.
Authors & Co-Authors
de Beer, Maria C.
United States, Lexington
University of Kentucky
United States, New York
The Graduate Center
van der Westhuyzen, Deneys R.
United States, Lexington
University of Kentucky
United States, New York
The Graduate Center
de Beer, Frederick C.
United States, Lexington
University of Kentucky
United States, New York
The Graduate Center
United States
Va Medical Center
Statistics
Citations: 119
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1161/ATVBAHA.108.178681
ISSN:
10795642
Research Areas
Health System And Policy
Noncommunicable Diseases