Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis
Birth Defects Research Part A - Clinical and Molecular Teratology, Volume 97, No. 8, Year 2013
Notification
URL copied to clipboard!
Description
BACKGROUND: This study examines gene-environment interaction between the MTHFR C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analytical approach on four studies that used similar methods. METHODS: We used logistic regression to analyze the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal MTHFR C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non-syndromic cleft palate (CP)] and control groups. RESULTS: There was a reduced risk of CL(P) with maternal folic acid use (p=0.008; OR=0.70, 95% CI: 0.65-0.94) and with supplements containing folic acid (p=0.028, OR=0.80, 95% CI: 0.65-0.94). Maternal smoking increased the risk of both CL(P) (p<10 e-3; OR=1.62, 95% CI: 1.35-1.95) and CP (p=0.028; OR=1.38, 95% CI: 1.04-1.83). No significant risk was observed with either maternal or fetal MTHFR C677T genotypes. CONCLUSION: This individual participant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes. Birth Defects Research (Part A) 97:509-514, 2013. © 2013 Wiley Periodicals, Inc.
Authors & Co-Authors
Butali, Azeez
United States, Iowa City
University of Iowa
Little, Julian H.
Canada, Ottawa
University of Ottawa
Chévrier, Cécile
France, Paris
Inserm
Cordier, Sylvaine
France, Paris
Inserm
Steegers-Theunissen, Régine P.M.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Nijmegen
Radboud University Medical Center
Jugessur, Astanand
Norway, Oslo
Folkehelseinstituttet
Australia, Melbourne
Royal Children's Hospital, Melbourne
Oladugba, Bola
Nigeria, Naukka
University of Nigeria
Mossey, Peter Anthony
United Kingdom, Dundee
University of Dundee
Statistics
Citations: 8
Authors: 8
Affiliations: 9
Identifiers
Doi:
10.1002/bdra.23133
ISSN:
15420752
Research Areas
Genetics And Genomics
Maternal And Child Health
Substance Abuse
Study Approach
Systematic review