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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Menstrual regulation by intramuscular injections of 16‐phenoxy‐tetranor PGE2 methyl sulfonylamide or vacuum aspiration. A randomized multicentre study
BJOG: An International Journal of Obstetrics & Gynaecology, Volume 94, No. 10, Year 1987
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Description
Summary. A multicentre trial was conducted to compare the efficacy and side‐effects of an intramuscularly administered PGE2 analogue and vacuum aspiration in women with a delay of up to 21 days in the expected onset of menses. A total of 473 such women were randomly allocated to treatment with either 16‐phenoxy‐W‐17, 18, 19, 20‐tetranor PGE2 methyl sulfonylamide (three intramuscular injections of 0.5 mg at 3‐h intervals) or vacuum aspiration, and the outcome of therapy assessed 1, 2 and 6–8 weeks later. Retrospective analysis of hCG levels indicated that 419 (88.6%) women had been pregnant at the time of treatment. With few exceptions, administration of the PGE2 analogue induced vaginal bleeding in both pregnant and non‐pregnant women but the duration and subjectively perceived amount of bleeding were greater than after vacuum aspiration. Both treatments were equally effective. In pregnant women the overall frequency of complete abortion was 91% for prostaglandin treatment and 94% for vacuum aspiration. If non‐pregnant women were included, the respective success rates (i.e. percentages of women not pregnant 2 weeks after treatment) were 92% and 95%. Gastrointestinal side‐effects and lower abdominal pain requiring intramuscular analgesia were more common after prostaglandin therapy than following vacuum aspiration in both pregnant and non‐pregnant women. Copyright © 1987, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Dhall, G. I.
Unknown Affiliation
Can, Nguyen
Unknown Affiliation
Andolsek‐Jeras, L.
Unknown Affiliation
Narone, J. N.
Unknown Affiliation
Jia‐Zheng, Chen
Unknown Affiliation
Hingorani, V.
Unknown Affiliation
Yu‐Fen, Zhou
Unknown Affiliation
Zhi‐Heng, Chen
Unknown Affiliation
Prasad, R. N.V.
Unknown Affiliation
Bygdeman, Marc S.
Unknown Affiliation
Herczeg, J.
Unknown Affiliation
Huai‐yin, Ye
Unknown Affiliation
Farley, Timothy M.M.
Unknown Affiliation
Rowe, P. I.
Unknown Affiliation
van Look, Paul F.A.
Unknown Affiliation
Statistics
Citations: 25
Authors: 15
Affiliations: 14
Identifiers
Doi:
10.1111/j.1471-0528.1987.tb02268.x
ISSN:
14700328
e-ISSN:
14710528
Research Areas
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female