Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy
Antimicrobial Agents and Chemotherapy, Volume 58, No. 6, Year 2014
Notification
URL copied to clipboard!
Description
This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7±8.0 liters [mean±standard deviation]) and clearance (20.2±7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure. © 2014, American Society for Microbiology.
Authors & Co-Authors
Roberts, Michael S.
Australia, Adelaide
University of South Australia
Australia, Woodville South
The Queen Elizabeth Hospital, North Western Adelaide Health Service
Warner, Morgyn S.
Australia, Adelaide
The University of Adelaide
Lipman, Jeffrey
Australia, Brisbane
Royal Brisbane and Women's Hospital
Australia, Brisbane
The University of Queensland
Peake, Sandra L.
Australia, Woodville South
The Queen Elizabeth Hospital, North Western Adelaide Health Service
Roberts, Jason A.
Australia, Adelaide
University of South Australia
Australia, Brisbane
Royal Brisbane and Women's Hospital
Australia, Brisbane
The University of Queensland
Statistics
Citations: 35
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1128/AAC.02340-14
ISSN:
00664804
Research Areas
Health System And Policy