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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Evolutionary history of hepatitis C virus genotype 5a in France, a multicenter ANRS study
Infection, Genetics and Evolution, Volume 11, No. 2, Year 2011
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Description
The epidemic history of HCV genotype 5a is poorly documented in France, where its prevalence is very low, except in a small central area, where it accounts for 14.2% of chronic hepatitis C cases. A Bayesian coalescent phylogenetic investigation based on the E1 envelope gene and a non-structural genomic segment (NS3/4) was carried out to trace the origin of this epidemic using a large sample of genotype 5a isolates collected throughout France. The dates of documented transmissions by blood transfusion were used to calibrate five nodes in the phylogeny. The results of the E1 gene analysis showed that the best-fitting population dynamic model was the expansion growth model under a relaxed molecular clock. The rate of nucleotide substitutions and time to the most recent common ancestors (tMRCA) of genotype 5a isolates were estimated. The divergence of all the French HCV genotype 5a strains included in this study was dated to 1939 [95% HPD: 1921-1956], and the tMRCA of isolates from central France was dated to 1954 [1942-1967], which is in agreement with epidemiological data. NS3/4 analysis provided similar estimates with strongly overlapping HPD values. Phylodynamic analyses give a plausible reconstruction of the evolutionary history of HCV genotype 5a in France, suggesting the concomitant roles of transfusion, iatrogenic route and intra-familial transmission in viral diffusion. © 2011 Elsevier B.V.
Authors & Co-Authors
Henquell, Cécile
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
France, Clermont-ferrand
Université Clermont Auvergne
Guglielmini, Julien
Belgium, Brussels
Université Libre de Bruxelles
Verbeeck, Jannick
Belgium, Leuven
Rega Institute for Medical Research
Mahul, Antoine
France, Clermont-ferrand
Université Clermont Auvergne
Thibault, Vincent
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Lebray, Pascal
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Laperche, Syria
France, Paris
Institut National de la Transfusion Sanguine
Trimoulet, Pascale
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Foucher, Juliette
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Le Guillou-Guillemette, Hélène
France, Angers
Chu Angers
Fouchard-Hubert, Isabelle
France, Angers
Chu Angers
Abravanel, Florence
France, Toulouse
Chu de Toulouse
Métivier, Sophie
France, Toulouse
Chu de Toulouse
Gaudy-Graffin, Catherine
France, Tours
Centre Hospitalier Regional et Universitaire de Tours
D'Alteroche, Louis
France, Tours
Centre Hospitalier Regional et Universitaire de Tours
Rosenberg, Arielle R.
France, Paris
Hopital Cochin Ap-hp
France, Paris
Université Paris Cité
Podevin, Philippe
France, Paris
Université Paris Cité
Plantier, Jean Christophe
France, Rouen
Chu Rouen Normandie
Riachi, Ghassan
France, Rouen
Chu Rouen Normandie
Saoudin, Henia
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
Coppere, Henri
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
André, Elisabeth
France, Nantes
Chu de Nantes
Gournay, Jérôme
France, Nantes
Chu de Nantes
Féray, Cyrille
France, Nantes
Chu de Nantes
Vallet, Sophie
France, Brest
Centre Hospitalier Universitaire de Brest
Nousbaum, Jean Baptiste
France, Brest
Centre Hospitalier Universitaire de Brest
Baazia, Yazid
France, Bobigny
Hopital Avicenne
Roulot, Dominique M.
France, Bobigny
Hopital Avicenne
Alain, Sophie
France, Limoges
Chu de Limoges
Loustaud-Ratti, Véronique
France, Limoges
Chu de Limoges
Schvoerer, Évelyne
France, Strasbourg
Les Hôpitaux Universitaires de Strasbourg
Habersetzer, François
France, Strasbourg
Les Hôpitaux Universitaires de Strasbourg
Pérez-Serra, Rafael Juan
Spain, Alicante
Hospital de Alcoy
Gourari, Samir
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Mirand, Audrey
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
Odent-Malaure, Hélène
France, Saint-denis-la-plaine
Etablissement Français du Sang
Garraud, Olivier
France, Saint-denis-la-plaine
Etablissement Français du Sang
Izopet, Jacques
France, Toulouse
Chu de Toulouse
Bommelaer, Gilles
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
Peigue-Lafeuille, Hélène
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
van Ranst, Marc A.
Belgium, Leuven
Rega Institute for Medical Research
Abergel, Armand
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
Bailly, Jean Luc
France, Clermont-ferrand
Université Clermont Auvergne
Statistics
Citations: 43
Authors: 43
Affiliations: 22
Identifiers
Doi:
10.1016/j.meegid.2010.12.015
ISSN:
15671348
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study