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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Percutaneous shunt reduction for the management of TIPS-induced acute liver decompensation: A follow-up study
Annals of Hepatology, Volume 15, No. 6, Year 2016
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Description
Background and rationale for the study. The purpose of this study was to assess the technical and clinical outcomes of transjugular intrahepatic portosystemic shunt (TIPS) reduction for the management of TIPS-induced acute liver decompensation. Between August 2000 and November 2013, 347 patients underwent a TIPS procedure in the authors’ institution; 21/347 (6%) developed post-TIPS acute liver decompensation which was managed using a percutaneous shunt reduction technique. Patient demographics, laboratory tests before and after initial TIPS and TIPS reduction, procedural data and clinical follow-up data were analysed. Results. Twenty-one patients (mean age 63 years) who underwent an initial TIPS procedure for variceal bleeding (n = 7; 33%) or refractory ascites (n = 14; 67%) successfully underwent shunt reduction ten days (3-34 days) after the initial TIPS procedure. The portosystemic pressure gradient (PSPG) increased from 8 (3-17) mmHg before reduction to 12 (7-23) mmHg after shunt reduction. Survival at one and six months follow-up was 15 (71%) and 11 patients (52%), respectively. The international normalised ratio (INR) (1.7 vs. 1.5; p = 0.044) was significantly different after TIPS reduction in the non-survival group compared to the survival group. In conclusion, TIPS reduction for the management of TIPS-induced acute liver decompensation is technically feasible and is associated with a one and six-month mortality rate of 29% and 48%, respectively. Higher post-TIPS-reduction INR values may be associated with higher risk of early mortality. © 2016, Fundacion Clinica Medica Sur. All rights reserved.
Authors & Co-Authors
Nevens, Frederik
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Laenen, Annouschka A.E.
Belgium, Hasselt
Universiteit Hasselt
Laleman, Wim J.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Verslype, Chris
Belgium, Leuven
Ku Leuven– University Hospital Leuven
van der Merwe, Schalk Willem
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Maleux, Geert Albert
Unknown Affiliation
Statistics
Citations: 11
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.5604/16652681.1222110
ISSN:
16652681
Research Areas
Health System And Policy
Study Design
Cohort Study