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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The relation of airway obstruction to asthma, chronic rhinosinusitis and age: Results from a population survey of adults
Allergy: European Journal of Allergy and Clinical Immunology, Volume 69, No. 9, Year 2014
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Description
Rationale There is conflicting evidence on whether patients with asthma experience an accelerated decline in lung function with age. We examined the association between postbronchodilator lung function, asthma, chronic rhinosinusitis (CRS), and atopy with age using a large European sample. Methods In 17 centers in 11 European countries, case-control studies were nested within representative cross-sectional surveys of adults aged less than 75 years. Representative samples of participants with asthma, CRS or both and controls were assessed for postbronchodilator ventilatory function, smoking history, atopy, and treatment. Multiple regression was used to assess the interactive effects of age and diagnostic group on decline in postbronchodilator ventilatory function. Results A total of 3337 participants provided adequate data (778 with asthma, 399 with CRS, 244 with both asthma and CRS and 1916 controls who had neither asthma nor CRS). Participants with asthma had lower FEV1/FVC (-4.09% (95% CI: -5.02, -3.15, P < 0.001) and a steeper slope of FEV 1/FVC against age (-0.14%/annum [95%CI: -0.19, -0.08]) equivalent to smoking 1-2 packs of cigarettes per day. Those with atopy had a slope equivalent to controls. Conclusions People with asthma have a steeper decline in postbronchodilator lung function with age, but neither CRS nor atopy alone were associated with such decline. © 2014 The Authors. Allergy Published by John Wiley & Sons Ltd.
Authors & Co-Authors
Obaseki, Daniel Osagbemworhue
Nigeria, Ife
Obafemi Awolowo University
United Kingdom, London
National Heart and Lung Institute
Potts, James F.
United Kingdom, London
National Heart and Lung Institute
Joos, Guy F.P.
Belgium, Ghent
Universitair Ziekenhuis Gent
Baelum, J.
Denmark, Odense
Odense Universitetshospital
Haahtela, Tari M.K.
Finland, Helsinki
Helsingin Yliopisto
Ahlström, M.
Finland, Helsinki
Helsingin Yliopisto
Matricardi, Paolo Maria
Germany, Berlin
Charité – Universitätsmedizin Berlin
Kramer, U.
Germany, Dusseldorf
Leibniz Research Institute for Environmental Medicine
Germany, Munich
Technische Universität München
Gjomarkaj, M.
Italy, Rome
Consiglio Nazionale Delle Ricerche
Fokkens, Wytske Johanna
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Makowska, Joanna Samanta
Poland, Lodz
Medical University of Lodz
Todo Bom, A. Maria
Portugal, Coimbra
Universidade de Coimbra, Faculdade de Medicina
Toreń, Kjell
Sweden, Gothenburg
Göteborgs Universitet
Janson, Christer
Sweden, Uppsala
Uppsala Universitet
Dahleń, Sven Erik K.
Sweden, Stockholm
Karolinska Institutet
Forsberg, Bertil
Sweden, Umea
Umeå Universitet
Jarvis, Deborah L.
United Kingdom, London
National Heart and Lung Institute
Howarth, Peter Hugo
United Kingdom, Southampton
Southampton General Hospital
Brozek, G.
Poland, Katowice
Slaski Uniwersytet Medyczny w Katowicach
Minov, J.
North Macedonia, Skopje
Institute for Occupational Health of Republic of Macedonia
Bachert, Claus
Belgium, Ghent
Universiteit Gent
Sweden, Stockholm
Karolinska Institutet
Burney, Peter G.J.
United Kingdom, London
National Heart and Lung Institute
Statistics
Citations: 29
Authors: 22
Affiliations: 20
Identifiers
Doi:
10.1111/all.12447
ISSN:
01054538
e-ISSN:
13989995
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative