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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cord blood V2Vδ2 T cells provide a molecular marker for the influence of pregnancy-associated malaria on neonatal immunity
Journal of Infectious Diseases, Volume 209, No. 10, Year 2014
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Description
Background. Plasmodium falciparum placental infection primes the fetal immune system and alters infant immunity. Mechanisms leading to these outcomes are not completely understood.We focused on Vγ2Vδ2 cells, which are part of the immune response against many pathogens, including P. falciparum. These unconventional lymphocytes respond directly to small, nonpeptidic antigens, independent of major histocompatibility complex presentation. We wondered whether placental malaria, which may increase fetal exposure to P. falciparum metabolites, triggers a response by neonatal V γ2Vδ2 lymphocytes that can be a marker for the extent of fetal exposure to malarial antigens. Methods. Cord blood mononuclear cells were collected from 15 neonates born to mothers with P. falciparum infection during pregnancy (8 with placental malaria) and 25 unexposed neonates. V γ2Vδ2 cell phenotype, repertoire, and proliferative responses were compared between newborns exposed and those unexposed to P. falciparum. Results. Placental malaria-exposed neonates had increased proportions of central memory Vγ2Vδ2 cells in cord blood, with an altered Vγ2 chain repertoire ex vivo and after stimulation. Conclusion. Our results suggest that placental malaria affects the phenotype and repertoire of neonatal Vγ2Vδ2 lymphocytes. Placental malaria may lower the capacity for subsequent V γ2Vδ2 cell responses and impair the natural resistance to infectious diseases or the response to pediatric vaccination. © 2013 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4007110/bin/supp_209_10_1653__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4007110/bin/supp_jit802_jit802supp.pdf
Authors & Co-Authors
Cairo, Cristiana
United States, Baltimore
Institute of Human Virology
Longinaker, Nyaradzo
United States, Baltimore
University of Maryland, Baltimore Umb
Cappelli, Giulia
United States
Chantal Biya International Reference Center for Research on Hiv/aids Prevention and Management
United States
National Council of Research
Léké, Rose Gana Fomban
France
University of Yaounde I
Ondo, Manuel O.
United States
Chantal Biya International Reference Center for Research on Hiv/aids Prevention and Management
Djokam, Rosine R.T.
France
University of Yaounde I
Fogako, Josephine
France
University of Yaounde I
Leke, Robert John Ivo
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Sagnia, Bertrand
United States
Chantal Biya International Reference Center for Research on Hiv/aids Prevention and Management
Sosso, Samuel Martin
United States
Chantal Biya International Reference Center for Research on Hiv/aids Prevention and Management
Colizzi, Vittorio C.
United States
Chantal Biya International Reference Center for Research on Hiv/aids Prevention and Management
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Pauza, Charles David
United States, Baltimore
Institute of Human Virology
Statistics
Citations: 22
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/jit802
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health