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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study
Anaesthesia, Volume 73, No. 10, Year 2018
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Description
The peri-operative use of angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers is thought to be associated with an increased risk of postoperative acute kidney injury. To reduce this risk, these agents are commonly withheld during the peri-operative period. This study aimed to investigate if withholding angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers peri-operatively reduces the risk of acute kidney injury following major non-cardiac surgery. Patients undergoing elective major surgery on the gastrointestinal tract and/or the liver were eligible for inclusion in this prospective study. The primary outcome was the development of acute kidney injury within seven days of operation. Adjusted multi-level models were used to account for centre-level effects and propensity score matching was used to reduce the effects of selection bias between treatment groups. A total of 949 patients were included from 160 centres across the UK and Republic of Ireland. From this population, 573 (60.4%) patients had their angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers withheld during the peri-operative period. One hundred and seventy-five (18.4%) patients developed acute kidney injury; there was no difference in the incidence of acute kidney injury between patients who had their angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers continued or withheld (107 (18.7%) vs. 68 (18.1%), respectively; p = 0.914). Following propensity matching, withholding angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers did not demonstrate a protective effect against the development of postoperative acute kidney injury (OR (95%CI) 0.89 (0.58–1.34); p = 0.567). © 2018 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists
Authors & Co-Authors
Drake, Thomas M.
Unknown Affiliation
Glasbey, James C.
Unknown Affiliation
Woin, Evelina
Unknown Affiliation
Fitzgerald, James Edward Frankland
Unknown Affiliation
Harrison, Ewen Munro
Unknown Affiliation
Nepogodiev, Dmitri
Unknown Affiliation
Claireaux, Henry Adam
Unknown Affiliation
Deekonda, Praveena
Unknown Affiliation
Gundogan, Buket
Unknown Affiliation
Kamarajah, Sivesh K.
Unknown Affiliation
Khatri, Chetan
Unknown Affiliation
Kong, C. Y.
Unknown Affiliation
McLean, Kenneth A.
Unknown Affiliation
McNamee, Lisa
Unknown Affiliation
Mohan, Midhun
Unknown Affiliation
Bhangu, Aneel Amir
Unknown Affiliation
Arulkumaran, Nishkantha
Unknown Affiliation
Bell, Samira
Unknown Affiliation
Duthie, Fiona A.I.
Unknown Affiliation
Hughes, Jeremy H.
Unknown Affiliation
Prowle, John R.
Unknown Affiliation
Richards, Toby A.
Unknown Affiliation
Dynes, Katie
Unknown Affiliation
Wigley, Catrin H.
Unknown Affiliation
Suresh, Reena S.
Unknown Affiliation
Shaw, Abigail V.
Unknown Affiliation
Klimach, Stefan G.
Unknown Affiliation
Jull, Patrick
Unknown Affiliation
Evans, David A.
Unknown Affiliation
Preece, Ryan A.
Unknown Affiliation
Ibrahim, Ibrahim Hassan
Unknown Affiliation
Manikavasagar, Venughanan
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Teo, Roxanne
Unknown Affiliation
Logan, Andrew E.
Unknown Affiliation
Barai, Ishani
Unknown Affiliation
Amin, Humzah
Unknown Affiliation
Sethi, Rajiv K.
Unknown Affiliation
Bolton, William S.
Unknown Affiliation
Corbridge, Olivia
Unknown Affiliation
Horne, Laura
Unknown Affiliation
Attalla, Mark S.
Unknown Affiliation
Morley, Rachael L.
Unknown Affiliation
Hoskins, Toby C.
Unknown Affiliation
McAllister, Ross
Unknown Affiliation
Dennis, Yoni F.
Unknown Affiliation
Heywood, Emily G.
Unknown Affiliation
Wilson, Holly A.
Unknown Affiliation
Ng, Li Yen
Unknown Affiliation
Samaraweera, Sahan Asela
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Doherty, Colin P.
Unknown Affiliation
Belchos, Jessica
Unknown Affiliation
Phan, Vivian
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Chouari, Tarak Agrebi Moumni
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Gardner, Timothy
Unknown Affiliation
Goergen, Nina
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Hayes, John D.B.
Unknown Affiliation
MacLeod, Caitlin S.
Unknown Affiliation
McCormack, Roisin
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McKinley, Aileen J.
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McKinstry, Scott
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Milligan, William
Unknown Affiliation
Ooi, L.
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Rafiq, Nasir Muhammad
Unknown Affiliation
Sammut, T.
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Sinclair, E.
Unknown Affiliation
Smith, Myles J.F.
Unknown Affiliation
Baker, Cara R.
Unknown Affiliation
Fearnhead, Nicola S.
Unknown Affiliation
Qureshi, Ahmad Uzair
Unknown Affiliation
Kelly, Michael Eamon
Unknown Affiliation
Evans, Richard P.T.
Unknown Affiliation
Hayat, Faisal
Unknown Affiliation
Blazeby, Jane M.
Unknown Affiliation
Harris, Lyndsay N.
Unknown Affiliation
Henry, Jaymie Ang
Unknown Affiliation
Wilson, Robert John
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Adamson, Roslin J.
Unknown Affiliation
Menon, David Krishna
Unknown Affiliation
Warren, Oliver J.
Unknown Affiliation
Toh, Cheng Hock
Unknown Affiliation
Harris, Sarah E.
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Nixon, Gemma
Unknown Affiliation
Jones, Laura L.
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Macdonald, Cameron L.
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Ryan, Greg
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Russell, John Desmond
Unknown Affiliation
Patel, Arjun
Unknown Affiliation
Vernet, Gabrielle
Unknown Affiliation
O'Brien, Mary Ann Thomson
Unknown Affiliation
Vella-Baldacchino, Martinique
Unknown Affiliation
Alfa-Wali, Maryam
Unknown Affiliation
Sim, Dayna P.Y.
Unknown Affiliation
Perry, Michael Scott
Unknown Affiliation
Ali, Ahmad K.
Unknown Affiliation
Mann, Harvinder S.
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McBride, Stephen J.
Unknown Affiliation
Innes, Richard
Unknown Affiliation
Boyles, Louise
Unknown Affiliation
Deepak, Shantal
Unknown Affiliation
Fowler, Alexander James
Unknown Affiliation
Neville, Jonathan James
Unknown Affiliation
Welsh, Kenneth I.
Unknown Affiliation
Gupta, Ajay Kumar
Unknown Affiliation
Bowley, Douglas M.G.
Unknown Affiliation
Kim, So-hee
Unknown Affiliation
Osman, Mohammed Farah
Unknown Affiliation
Anwar, Sumadi L.
Unknown Affiliation
Rammell, James
Unknown Affiliation
Andrews, Howard F.
Unknown Affiliation
Ahmed, Parvez A.
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Davies, Gareth L.
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Waterman, Ade
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Francis, Nader Kamal
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Chenciner, Louisa
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Watson, Nicholas F.S.
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Merchant, Nipun B.
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Spiers, Harry V.M.
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Bath, Michael F.
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Hussein, Naglaa A.
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Williams, Colin Y.
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Osei-Bordom, Daniel Clement
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Bannard-Smith, Jonathan P.
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Bennett, Michael H.
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McAlinden, Colm
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Cato, Liam David
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Mahmood, Raja Tahir
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Ibrahim, Basil Mohamed Salabeldin
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Khalil, Mohammed Hassene
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Mittapalli, Devender
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Khaliq, Mehnoor
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Robinson, Stephen D.
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Shaw, Catherine A.
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Jones, Elizabeth
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Hilton, Joan F.
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Akhbari, Melika
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Koshy, Renol Mathew
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Qamar, Mubasher A.
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Carter, Nicholas C.
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Lawday, Samuel
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Pinkney, Thomas D.
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Butler, Anthony Philip Howard
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Davies, Eleanor
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Ngaage, Ledibabari Mildred
Unknown Affiliation
Hamid, Hytham K.S.
Unknown Affiliation
McLean, Aaron Lawson
Unknown Affiliation
Belgaid, Dorsaf R.
Unknown Affiliation
Burke, Joshua Richard
Unknown Affiliation
Omar, Islam
Unknown Affiliation
Chan, Matthew Tak Vai
Unknown Affiliation
Moug, Susan Joan
Unknown Affiliation
Nair, Ashitha
Unknown Affiliation
Cunningham, Larry L.
Unknown Affiliation
Francis, Susan T.
Unknown Affiliation
Rangarajan, Sumathy
Unknown Affiliation
Teng, Tiew-Hwa Katherine
Unknown Affiliation
Mathew, Bipin
Unknown Affiliation
Turner, Stephen T.
Unknown Affiliation
Spencer, Rebecca G.
Unknown Affiliation
Moore, Timothy Alan
Unknown Affiliation
Davies, E. Bethan
Unknown Affiliation
Rana, Surinder S.
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Abbott, Tom Ef
Unknown Affiliation
Morgan, Catrin
Unknown Affiliation
Nicholls, Kathleen M.
Unknown Affiliation
Logan, Peter C.
Unknown Affiliation
Statistics
Citations: 26
Authors: 165
Identifiers
Doi:
10.1111/anae.14349
ISSN:
00032409
Research Areas
Health System And Policy
Noncommunicable Diseases
Violence And Injury
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative