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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of blood tests for liver fibrosis specific or not to NAFLD
Journal of Hepatology, Volume 50, No. 1, Year 2009
Notification
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Description
Background/Aims: To compare blood tests of liver fibrosis specific for NAFLD: the FibroMeter NAFLD and the NAFLD fibrosis score (NFSA) with a non-specific test, APRI. Methods: Two hundred and thirty-five NAFLD patients with liver Metavir staging and blood markers from two independent centres were randomly assigned to a test (n = 121) or a validation population (n = 114). Results: The highest accuracy - 91% - for significant fibrosis was obtained with the FibroMeter whose (i) AUROC (0.943) was significantly higher than those of NFSA (0.884, p = 0.008) and APRI (0.866, p < 10-3; p = 0.309 vs NFSA) in the whole population, and (ii) misclassification rate (9%) was significantly lower than those of NFSA (14%, p = 0.04) and APRI (16%, p = 0.002) and did not vary according to centre (14 vs 7%, p = 0.07), unlike those of NFSA (25 vs 9%, p = 0.001) and APRI (29 vs 11%, p < 10-3). By using thresholds of 90% predictive values, liver biopsy could have been avoided in most patients: FibroMeter: 97.4% vs NFSA: 86.8% (p < 10-3) and APRI: 80.0% (p < 10-3). A new classification provided three reliable diagnosis intervals: F0/1, F0/1/2, F2/3/4 with 91.4% accuracy for FibroMeter, avoiding biopsy in all patients. Conclusions: FibroMeter NAFLD had high performance and provided reliable diagnosis for significant fibrosis, significantly outperforming NFSA and APRI. © 2008 European Association for the Study of the Liver.
Authors & Co-Authors
Calès, Paul
France, Angers
Chu Angers
France, Angers
Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques
Lainé, Fabrice
France, Rennes
Hôpital Pontchaillou
Boursier, Jérôme
France, Angers
Chu Angers
France, Angers
Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques
Deugnier, Yves
France, Rennes
Hôpital Pontchaillou
Moal, Valérie
France, Angers
Chu Angers
Oberti, Frédèric
France, Angers
Chu Angers
France, Angers
Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques
Hunault, Gilles
France, Angers
Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques
Rousselet, Marie Christine
France, Angers
Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques
France, Angers
Chu Angers
Hubert, Isabelle
France, Angers
Chu Angers
France, Angers
Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques
Laafi, Jihane
France, Angers
Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Ducluzeaux, Pierre Henri
France, Angers
Chu Angers
Lunel-Fabiani, Françoise
France, Angers
Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques
France, Angers
Chu Angers
Statistics
Citations: 262
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/j.jhep.2008.07.035
ISSN:
01688278
Study Design
Cross Sectional Study