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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
The entomological inoculation rate and Plasmodium falciparum infection in African children
Nature, Volume 438, No. 7067, Year 2005
Notification
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Description
Malaria is an important cause of global morbidity and mortality. The fact that some people are bitten more often than others has a large effect on the relationship between risk factors and prevalence of vector-borne diseases. Here we develop a mathematical framework that allows us to estimate the heterogeneity of infection rates from the relationship between rates of infectious bites and community prevalence. We apply this framework to a large, published data set that combines malaria measurements from more than 90 communities. We find strong evidence that heterogeneous biting or heterogeneous susceptibility to infection are important and pervasive factors determining the prevalence of infection: 20% of people receive 80% of all infections. We also find that individual infections last about six months on average, per infectious bite, and children who clear infections are not immune to new infections. The results have important implications for public health interventions: the success of malaria control will depend heavily on whether efforts are targeted at those who are most at risk of infection. © 2005 Nature Publishing Group.
Authors & Co-Authors
Smith, David L.
United States, Bethesda
National Institutes of Health Nih
Dushoff, Jonathan G.
United States, Bethesda
National Institutes of Health Nih
United States, Princeton
Princeton University
Snow, Robert William
Kenya, Nairobi
Kenyatta National Hospital
United Kingdom, Oxford
University of Oxford
Hay, Simon I.
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 370
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1038/nature04024
ISSN:
00280836
e-ISSN:
14764687
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study