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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study
Journal of Affective Disorders, Volume 256, Year 2019
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Description
Background: Little is known about the respective effects of depression and cognitive impairment on quality of life among older adults with schizophrenia spectrum disorder. Methods: We used data from the Cohort of individuals with Schizophrenia Aged 55-years or more (CSA) study, a large multicenter sample of older adults with schizophrenia or schizoaffective disorder (N = 353). Quality of life (QoL), depression and cognitive impairment were assessed using the Quality of Life Scale (QLS), the Center of Epidemiologic Studies Depression scale and the Mini-Mental State Examination, respectively. We used structural equation modeling to examine the shared and specific effects of depression and cognitive impairment on QoL, while adjusting for sociodemographic characteristics, general medical conditions, psychotropic medications and the duration of the disorder. Results: Depression and cognitive impairment were positively associated (r = 0.24, p < 0.01) and both independently and negatively impacted on QoL (standardized β = −0.41 and β = −0.32, both p < 0.01) and on each QLS quality-of-life domains, except for depression on instrumental role and cognitive impairment on interpersonal relations in the sensitivity analyses excluding respondents with any missing data. Effects of depression and cognitive impairment on QoL were not due to specific depressive symptoms or specific cognitive domains, but rather mediated through two broad dimensions representing the shared effects across all depressive symptoms and all cognitive deficits, respectively. Limitations: Because of the cross-sectional design of this study, measures of association do not imply causal associations. Conclusions: Mechanisms underlying these two broad dimensions should be considered as important potential targets to improve quality of life of this vulnerable population. © 2019
Authors & Co-Authors
Hoertel, Nicolas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Inserm
France, Paris
Université Paris Cité
Blanco, Carlos V.
United States, Bethesda
National Institute on Drug Abuse Nida
Adès, Jean
Unknown Affiliation
Amado, Isabelle Reine
Unknown Affiliation
Dubertret, Caroline
Unknown Affiliation
Guillin, Olivier
Unknown Affiliation
Haffen, Emmanuel
Unknown Affiliation
Jalenques, Isabelle
Unknown Affiliation
Kébir, Oussama
Unknown Affiliation
Krebs, Marie Odile
Unknown Affiliation
Leboyer, Marion
Unknown Affiliation
Llorca, Pierre Michel
Unknown Affiliation
Lucas, Stephane
Unknown Affiliation
Mahi, Mohammed
Unknown Affiliation
Nubukpo, Philippe
Unknown Affiliation
Pringuey, Dominique J.
Unknown Affiliation
Sechter, Daniel
Unknown Affiliation
Verdoux, Hélène
Unknown Affiliation
Statistics
Citations: 17
Authors: 18
Affiliations: 8
Identifiers
Doi:
10.1016/j.jad.2019.05.063
ISSN:
01650327
Research Areas
Disability
Mental Health
Study Design
Cross Sectional Study
Cohort Study