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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Sangassou virus, the first hantavirus isolate from africa, displays genetic and functional properties distinct from those of other Murinae-associated hantaviruses
Journal of Virology, Volume 86, No. 7, Year 2012
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Description
We have discovered the first indigenous African hantavirus, Sangassou virus (SANGV). The virus was isolated from an African wood mouse (Hylomyscus simus), trapped in a forest habitat in Guinea, West Africa. Here, we report on the characterization of the genetic and functional properties of the virus. The complete genome of SANGV was determined and showed typical hantavirus organization. The small (S), medium (M), and large (L) genome segments containing genes encoding nucleocapsid protein, two envelope glycoproteins, and viral polymerase were found to be 1,746, 3,650, and 6,531 nucleotides long, respectively. The exact 5' and 3' termini for all three segments of the SANGV genome were determined and were predicted to form the panhandle structures typical of bunyaviruses. Phylogenetic analyses of all three segment sequences confirmed SANGV as a Murinaeassociated hantavirus most closely related to the European Dobrava-Belgrade virus. We showed, however, that SANGV usesβ1 integrin rather thanβ3 integrin and decay-accelerating factor (DAF)/CD55 as an entry receptor. In addition, we demonstrated a strong induction of type III lambda interferon (IFN-λ) expression in type I IFN-deficient Vero E6 cells by SANGV. These properties are unique within Murinae-associated hantaviruses and make the virus useful in comparative studies focusing on hantavirus pathogenesis. © 2012, American Society for Microbiology.
Authors & Co-Authors
Klempa, Boris
Germany, Berlin
Charité – Universitätsmedizin Berlin
Slovakia, Bratislava
Institute of Virology Slovak Academy of Sciences
Witkowski, P. T.
Germany, Berlin
Charité – Universitätsmedizin Berlin
Popugaeva, Elena
Germany, Berlin
Charité – Universitätsmedizin Berlin
Auste, Brita
Germany, Berlin
Charité – Universitätsmedizin Berlin
Koivogui, Lamine
Guinea, Conakry
Université de Conakry
Fichet-Calvet, Elisabeth
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Strecker, Thomas
Germany, Marburg
Philipps-universität Marburg
Ter Meulen, Jan H.
Germany, Marburg
Philipps-universität Marburg
Kruger, Detlev H.
Germany, Berlin
Charité – Universitätsmedizin Berlin
Statistics
Citations: 45
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1128/JVI.05879-11
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Genetics And Genomics
Study Locations
Multi-countries
Guinea