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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Glycoxydation promotes vascular damage Via MAPK-ERK/JNK pathways
Journal of Cellular Physiology, Volume 227, No. 11, Year 2012
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Description
Oxidation and glycation enhance foam cell formation via MAPK/JNK in euglycemic and diabetic subjects. Here, we investigated the effects of glycated and oxidized LDL (glc-oxLDL) on MAPK-ERK and JNK signaling pathways using human coronary smooth muscle cells. Glc-oxLDL induced a broad cascade of MAPK/JNK-dependent signaling transduction pathways and the AP-1 complex. In glc-oxLDL treated coronary arterioles, tumor necrosis factor (TNF) α increased JNK phosphorylation, whereas protein kinase inhibitor dimethylaminopurine (DMAP) prevented the TNF-induced increase in JNK phosphorylation. The role of MKK4 and JNK were then investigated in vivo, using apolipoprotein E knockout (ApoE-/-) mice. Peritoneal macrophages, isolated from spontaneously hyperlipidemic but euglycemic mice showed increases in both proteins and phosphorylated proteins. Compared to streptozotocin-treated diabetic C57BL6 and nondiabetic C57BL6 Wt mice, in streptozotocin-diabetic ApoE-/- mice, the increment of foam cell formation corresponded to an increment of phosphorylation of JNK1, JNK2, and MMK4. Thus, we provide a first line of evidence that MAPK-ERK/JNK pathways are involved in vascular damage induced by glycoxidation. © 2012 Wiley Periodicals, Inc.
Authors & Co-Authors
de Nigris, Filomena
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Rienzo, Monica
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Sessa, Marcella
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Infante, Teresa
Italy, Naples
Irccs Fondazione Sdn
Cesario, Elena
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Ignarro, Louis J.
United States, Los Angeles
University of California, Los Angeles
Al-Omran, Mohammed A.
Saudi Arabia, Riyadh
College of Medicine
Giordano, Antonio V.
United States, Philadelphia
Temple University
Palinski, Wulf
United States, La Jolla
University of California, San Diego
Napoli, Claudio
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Italy, Naples
Irccs Fondazione Sdn
Statistics
Citations: 10
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1002/jcp.24070
ISSN:
00219541
e-ISSN:
10974652
Research Areas
Cancer