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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Neutrophil CD64 as a diagnostic marker of sepsis in neonates
Journal of Investigative Medicine, Volume 62, No. 3, Year 2014
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Description
Background: Sepsis in neonates hospitalized in the neonatal intensive care unit is a global problem and is a significant contributor to morbidity and mortality. Neutrophil surface CD64, the high-affinity Fc receptor, is quantitatively up-regulated during infection and sepsis. Objective: Our goal in this prospective study was to measure the neutrophil CD64 in blood as an adjunct to our previously validated hematologic scoring system for detecting neonatal sepsis. Methods: A prospective study enrolled newborns with documented sepsis (n = 25), clinical sepsis (n = 25), and control newborns (n = 25). C-reactive protein, neutrophil CD64, complete blood counts, and blood cultures were taken. Neutrophil CD64 was analyzed by flow cytometry. Results: CD64 was significantly elevated in the groups with documented and clinical sepsis (P < 0.001). CD64 had a sensitivity of 96%, a specificity of 100%, a positive predictive value of 96.2%, and a negative predictive value of 100% with a cutoff value of 45.8% and 46.0% in the confirmed and the clinical sepsis groups, respectively. Conclusions: CD64 expression on neutrophils increases significantly in neonates with sepsis and can be considered a useful diagnostic marker for early diagnosis of neonatal infection as a single determination compared with other inflammatory markers. Copyright © 2014 by The American Federation for Medical Research.
Authors & Co-Authors
Elawady, Sanaa
Egypt, Giza
Cairo University
Botros, Shahira Kamal Anis
Egypt, Giza
Cairo University
Sorour, Ashraf E.
Egypt, Giza
Cairo University
Ghany, Eman Abdel
Egypt, Giza
Cairo University
Elbatran, Gamal
Egypt, Giza
Cairo University
Ali, Raghdaa
Egypt, Giza
Cairo University
Statistics
Citations: 36
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.2310/JIM.0000000000000060
ISSN:
10815589
e-ISSN:
17088267
Research Areas
Maternal And Child Health
Study Design
Cohort Study