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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cribriform-morular variant of papillary thyroid carcinoma displaying poorly differentiated features
International Journal of Surgical Pathology, Volume 21, No. 4, Year 2013
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Description
Cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) usually occurs in the setting of familial adenomatous polyposis (FAP) although it can rarely arise sporadically. Poorly differentiated thyroid carcinoma (PDTC) is a follicular cell-derived neoplasm with more aggressive behavior than well-differentiated carcinomas such as CMVPTC. We report the case of a 35-year-old woman without FAP history who presented a left neck mass and complained of back pain. Imagiological examinations revealed a nodule in the left lobe of thyroid and multiple nodular lesions in the bone and lungs suggestive of metastases. The patient was submitted to total thyroidectomy and radioactive iodine. The tumor was composed of CMVPTC and PDTC components that shared the same somatic APC gene mutation (p.Cys520Tyr-fsX534). Besides this mutation, no CTNNB1, BRAF, N-RAS, and H-RAS gene mutations were detected in any of the 2 components. To the best of our knowledge, this is the first report of a sporadic CMVPTC with transformation into PDTC. Although the majority of CMVPTCs carry an indolent clinical outcome, the coexistence of poorly differentiated areas may justify the aggressiveness of the CMVPTC reported here. © The Author(s) 2013.
Authors & Co-Authors
Nakazawa, Tadao
Portugal, Porto
Universidade do Porto
Japan, Kofu
University of Yamanashi
Celestino, Ricardo
Portugal, Porto
Universidade do Porto
Machado, J. C.
Portugal, Porto
Universidade do Porto
Cameselle-Teijeiro, Josè Manuel
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Vinagre, João
Portugal, Porto
Universidade do Porto
Eloy, Catarina
Portugal, Porto
Universidade do Porto
Portugal, Porto
St. João Central Hospital
Benserai, Fátima
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Lameche, Samia
Algeria, Algiers
Centre Hospitalier et Universitaire de Béni-messous, Algiers
Soares, Paula
Portugal, Porto
Universidade do Porto
Portugal, Porto
St. João Central Hospital
Sobrinho-Simòes, Manuel A.
Portugal, Porto
Universidade do Porto
Portugal, Porto
St. João Central Hospital
Statistics
Citations: 38
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1177/1066896912473355
ISSN:
10668969
e-ISSN:
19402465
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Participants Gender
Female