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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparative study on the efficacy and acceptability of two contraceptive pills administered by the vaginal route: An international multicenter clinical trial
Clinical Pharmacology & Therapeutics, Volume 53, No. 1, Year 1993
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Description
The efficacy and acceptability of two widely used oral contraceptive tablets, one containing 250 mg levonorgestrel and 50 µg ethinyl estradiol and the other containing 150 μg desogestrel and 30 µg ethinyl estradiol, administered by the vaginal route were compared in 1055 women studied over 12,630 woman‐months of vaginal contraceptive pill use. This multicenter clinical trial was performed in nine countries of the developing world by the “South to South Cooperation in Reproductive Health,” an organization founded by scientists from the Third World working in the area of reproductive health, and the study was developed and coordinated by one of these centers. The findings of this study confirm the efficacy of both these tablets when administered by the vaginal route. Involuntary pregnancy rates at 1 year of 2.78 for subjects in the levonorgestrel group and 4.54 for subjects the desogestrel group showed no statistically significant difference between the two groups. However, total discontinuation rates of 47.01 for subjects in the levonorgestrel group and 56.33 for subjects in the desogestrel group showed a statistically significant difference between the two groups, and discontinuation rates attributable to prolonged bleeding of 0.6 for subjects in the levonorgestrel group and 3.2 for subjects in the desogestrel group were also significantly higher in the group of subjects using the desogestrel vaginal contraceptive pill. Blood pressure remained at admission values throughout treatment. A statistically significant weight increase from admission values occurred in both groups of subjects. Clinical Pharmacology and Therapeutics (1993) 53, 65–75; doi: © 1993 American Society for Clinical Pharmacology and Therapeutics
Authors & Co-Authors
Coutinho, Elsimar Metzker
Brazil, Salvador
Universidade Federal da Bahia
De Souza, Jose Carlos
Brazil, Salvador
Universidade Federal da Bahia
Silva, Ana Rita da
Brazil, Salvador
Universidade Federal da Bahia
de Acosta, Oscar Mateo
Cuba, Havana
Instituto Nacional de Endocrinologia y Enfermedades Metabolicas
Alvarez-Sánchez, Francisco
Dominican Republic, Santo Domingo
Profamilia
Brache, Vivian
Dominican Republic, Santo Domingo
Profamilia
Flores, Josue Garza
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Vasquez‐Estrada, L.
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Santo, R.
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Bassol, S.
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Alvarado, G.
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Gu, Zhi Ping
China, Shanghai
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Ladipo, Oladapo Alabi
Nigeria, Ibadan
University of Ibadan
Adekunle, Adeyemi O.
Nigeria, Ibadan
University of Ibadan
Otolorin, Emmanuel O.
Nigeria, Ibadan
University of Ibadan
Mati, Japheth K.G.
Kenya, Nairobi
University of Nairobi
Maggwa, A. B.N.
Kenya, Nairobi
University of Nairobi
Shaaban, Mamdouh Mohamed
Egypt, Asyut
Assiut University
Sayed, Ezzat H.
Egypt, Asyut
Assiut University
Abdel-Aleem, Hany
Egypt, Asyut
Assiut University
Sikazwe, Nsama C.
Zambia, Lusaka
University of Zambia
Segal, Sheldon J.
United States, New York
Rockefeller Foundation
Statistics
Citations: 22
Authors: 22
Affiliations: 10
Identifiers
Doi:
10.1038/clpt.1993.10
ISSN:
00099236
e-ISSN:
15326535
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Participants Gender
Female