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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Recurrent pregnancy loss due to familial and non-familial habitual molar pregnancy
International Journal of Gynecology and Obstetrics, Volume 83, No. 2, Year 2003
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Description
Objectives: To present a series of women with recurrent molar pregnancies, including rare familial cases, and discuss etiology and treatment options. Methods: We performed a detailed clinical evaluation and pedigree analysis of five Egyptian women with recurrent pregnancy loss due to molar pregnancy. Results: The women had a history of four to nine consecutive hydatidiform moles but of no viable pregnancies. Two of the women had molar pregnancies with different husbands who themselves had viable offspring from previous wives; and three of them, who belonged to a family with extensive intermarriage, had a pedigree consistent with an autosomal recessive maternal-effect mutation. Conclusions: Recurrent pregnancy loss due to habitual molar pregnancy is uncommon and familial cases are extremely rare. The etiology of this disorder is not well understood but likely results from a maternal-effect mutation. Management options are limited, especially for couples who desire to have their own genetic offspring. © 2003 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Al-Hussaini, Tarek Khalaf
Egypt, Asyut
Assiut University
Abd-El-Aal, Diaa Eldeen Mohamed
Egypt, Asyut
Assiut University
Van den Veyver, I. B.
United States, Houston
Baylor College of Medicine
Statistics
Citations: 34
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/S0020-7292(03)00209-1
ISSN:
00207292
Research Areas
Cancer
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female