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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
IL-10 modulates fondaparinux inhibition of monocyte-induced thrombin generation
Journal of Thrombosis and Thrombolysis, Volume 32, No. 3, Year 2011
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Description
In addition to its established immuno-regulating capacity, the anti-inflammatory cytokine interleukin (IL)-10 exerts direct effects on coagulation. IL-10 down regulates the expression of tissue factor (TF) and thrombin generation (TG). Thus, we hypothesised that IL-10 could enhance the effect of anticoagulants. To evaluate in vitro the potential additive effect of IL-10 on fondaparinuxinduced anticoagulation. Human monocytes were purified by elutriation, and were activated by factor Xa (FXa). Realtime RT-PCR and Western blotting were used to evaluate FXa-induced TF synthesis. TG test was used as a functional test to assess TF-dependent monocyte procoagulation, and to evaluate the effects of IL-10 (200 and 500 pg/ ml) and fondaparinux (0.0, 0.1, 0.4, 0.7 and 1.2 lg/ml), separately and in combination. We confirmed that FXa induced TF mRNA and protein synthesis by monocyte in a concentration dependent manner. We showed that FXaactivated monocytes triggered TG via TF expression. We reported that IL-10 inhibited TG with a marginal effect seen at 200 pg/ml. Results with fondaparinux showed a concentration-dependent TG inhibition. The combination of IL-10 and fondaparinux effects demonstrated that IL-10: (i) potentiates the inhibitory effect of fondaparinux on TG by 10-30%, and (ii) dramatically modifies fondaparinux IC50 for each TG parameter. IL-10 enhances in vitro the extent of anticoagulation induced by fondaparinux. © Springer Science+Business Media, LLC 2011.
Authors & Co-Authors
Ben-Hadj-Khalifa, Sonia
Tunisia, Monastir
Faculté de Pharmacie de Monastir
France, Reims
Hopital Robert Debre Chu de Reims
Hézard, Nathalie
France, Reims
Hopital Robert Debre Chu de Reims
France, Reims
Université de Reims Champagne-ardenne
Almawi, Wassim Y.
Bahrain, Manama
Arabian Gulf University
Lakbakbi, Souad
France, Reims
Hopital Robert Debre Chu de Reims
France, Reims
Université de Reims Champagne-ardenne
Macé, Catherine
France, Reims
Hopital Robert Debre Chu de Reims
Cornillet-Lefebvre, P.
Tunisia, Monastir
Faculté de Pharmacie de Monastir
France, Reims
Hopital Robert Debre Chu de Reims
Mahjoub, Touhami
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Nguyên, Philippe H.
France, Reims
Université de Reims Champagne-ardenne
Statistics
Citations: 8
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1007/s11239-011-0618-1
ISSN:
09295305
e-ISSN:
1573742X