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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis, antimicrobial activity and conformational analysis of novel substituted pyridines: BF
3
-promoted reaction of hydrazine with 2-alkoxy pyridines
Bioorganic and Medicinal Chemistry, Volume 12, No. 8, Year 2004
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Description
Some new 2-alkoxy-3-cyano-4,6-diarylpyridines 3,4 were synthesized by condensation of different α,β-unsaturated ketones 1 with malononitrile 2, followed by cyclization in sodium alkoxide/alcohol system. Lewis acid-catalyzed reaction of 4 with hydrazine afforded the corresponding 1H-pyrazolo[3,4-b]pyridines 5. The potency of the results as antimicrobial agents has been evaluated. The structure of the newly prepared compounds was assessed by microanalysis, IR and NMR spectra. Molecular mechanics (MM2) and semiemperical (AM1) molecular orbital calculations have been performed for the most biologically active compounds 5b and c to get insight into their molecular structures and to learn more about their stable molecular conformations. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Goda, Fatma E.
Egypt, Mansoura
Faculty of Pharmacy
Abdel-Aziz, Alaa A.M.
Egypt, Mansoura
Mansoura University
Attef, Omer A.
United Arab Emirates, Ajman
Ajman University
Statistics
Citations: 111
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1016/j.bmc.2004.01.040
ISSN:
09680896
Research Areas
Substance Abuse