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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, Central African Republic
BMC Pediatrics, Volume 12, Article 191, Year 2012
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Description
Background: Tuberculosis (TB) is a major cause of childhood morbidity and mortality in developing countries. One of the main difficulties is obtaining adequate specimens for bacteriological confirmation of the disease in children.The aim of this study is to evaluate the adequacy of fine-needle aspiration (FNA) for the diagnosis of TB.Methods: In a prospective study conducted at the paediatric hospital in Bangui in 2007-2009, we used fine-needle aspiration to obtain samples for diagnosis of TB from 131 children aged 0-17 years with persistent lymphadenitis.Results: Fine-needle aspiration provided samples that could be used for bacteriological confirmation of TB. Ziehl-Neelsen staining for acid-fast bacilli was positive in 42.7% of samples, and culture identified TB in 67.2% of cases. Of 75 samples that were stain-negative, 49 (65.3%) were culture-positive, while 12 stain-positive samples remained culture-negative. Ten of the 12 stain-positive, culture-negative samples were from patients who had received previous antimicrobial therapy. With regard to phenotypic drug susceptibility, 81/88 strains (91.1%) were fully susceptible to isoniazid, rifampicin, ethambutol and streptomycin, six (6.8%) were resistant to one drug, and one multidrug-resistant strain was found.Conclusions: Fine-needle aspiration is simple, cost-effective and non-invasive and can be performed by trained staff. Combined with rapid molecular diagnostic tests, fine-needle aspirates could improve the diagnosis of TB and provide valuable information for appropriate treatment and drug resistance. © 2012 Fanny et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Minime-Lingoupou, Fanny
Central African Republic, Bangui
Institut Pasteur de Bangui
Beyam, Narcisse
Central African Republic, Bangui
Institut Pasteur de Bangui
Gody, Jean Chrysostome
Central African Republic
Hôpital Pédiatrique de Bangui
Zandanga, Germain
Central African Republic, Bangui
Institut Pasteur de Bangui
Yango, François
Central African Republic, Bangui
Institut Pasteur de Bangui
Manirakiza, Alexandre
Central African Republic, Bangui
Institut Pasteur de Bangui
Rigouts, Leen
Belgium, Antwerpen
Universiteit Antwerpen
Pierre-Audigier, Catherine
France, Paris
Institut Pasteur, Paris
Gicquel, Brigitte M.E.
France, Paris
Institut Pasteur, Paris
Bobossi Séréngbé, Gustave S.
Central African Republic
Hôpital Pédiatrique de Bangui
Statistics
Citations: 23
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1186/1471-2431-12-191
e-ISSN:
14712431
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Central African Republic