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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study
eBioMedicine, Volume 85, Article 104309, Year 2022
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Description
Background: After initiating antiretroviral therapy (ART), approximately 25% of people with HIV (PWH) may develop Immune Reconstitution Inflammatory Syndrome (IRIS), which is associated with increased morbidity and mortality. Several reports have demonstrated that low haemoglobin (Hb) levels are a risk factor for IRIS. To what extent the severity of anaemia contributes to the risk of IRIS and/or death is still insufficiently explored. Methods: We investigated both the presence and severity of anaemia in PWH in a multinational cohort of ART-naïve patients. A large panel of plasma biomarkers was measured pre-ART and patients were followed up for 6 months. IRIS or deaths during this period were considered as outcomes. We performed multidimensional analyses, logistic regression, and survival curves to delineate associations. Findings: Patients with severe anaemia (SA) presented a distinct systemic inflammatory profile, characterized by higher TNF, IL-6, and IL-27 levels. SA was independently associated with IRIS, with a higher risk of both early IRIS onset and death. Among IRIS patients, those with SA had a higher risk of mycobacterial IRIS. Interpretation: PWH with SA display a more pronounced inflammatory profile, with an elevated risk of developing IRIS earlier and a statistically significant higher risk of death. Funding: Intramural Research Program of National Institute of Allergy and Infectious Diseases/ National Institutes of Health (NIAID/NIH). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance code: 001) and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. © 2022 The Author(s)
Authors & Co-Authors
Araújo-Pereira, Mariana
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Multinational Organization Network Sponsoring Translational and Epidemiological Research Monster Initiative
Brazil, Salvador
Universidade Federal da Bahia
Sheikh, Virginia
United States, Bethesda
National Institutes of Health Nih
Sereti, Irini
United States, Bethesda
National Institutes of Health Nih
Barreto-Duarte, Beatriz
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Multinational Organization Network Sponsoring Translational and Epidemiological Research Monster Initiative
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Brazil, Salvador
Universidade Salvador
Arriaga, M. B.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Multinational Organization Network Sponsoring Translational and Epidemiological Research Monster Initiative
Brazil, Salvador
Universidade Federal da Bahia
Tibúrcio, Rafael T.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Multinational Organization Network Sponsoring Translational and Epidemiological Research Monster Initiative
Brazil, Salvador
Universidade Federal da Bahia
Vinhaes, Caian Leal
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Multinational Organization Network Sponsoring Translational and Epidemiological Research Monster Initiative
Brazil, Salvador
Escola Bahiana de Medicina e Saúde Pública – Ebmsp
Wang, Jing
United States, Reston
Leidos Inc.
Rupert, Adam W.
United States, Bethesda
National Institutes of Health Nih
Roby, Gregg A.
United States, Bethesda
National Institutes of Health Nih
Shaffer, Douglas N.
United States, Bethesda
Henry Jackson Foundation Medical Research International
United States, Silver Spring
Walter Reed Army Institute of Research
Ananworanich, Jintanat
United States, Rockville
Hjf
Phanuphak, Nittaya
Thailand, Bangkok
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Sawe, Fredrick Kipyego
United States, Bethesda
Henry Jackson Foundation Medical Research International
Andrade, Bruno B.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Multinational Organization Network Sponsoring Translational and Epidemiological Research Monster Initiative
Brazil, Salvador
Universidade Federal da Bahia
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Brazil, Salvador
Universidade Salvador
Statistics
Citations: 3
Authors: 15
Affiliations: 12
Identifiers
Doi:
10.1016/j.ebiom.2022.104309
ISSN:
23523964
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative