Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of iron deficiency anemia and its treatment on cell mediated immunity
Indian Journal of Hematology and Blood Transfusion, Volume 25, No. 2, Year 2009
Notification
URL copied to clipboard!
Description
Iron deficiency anemia (IDA) is one of the most prevalent micronutrient deficiencies particularly in the developing countries. While there is evidence of an altered immune profile in iron deficiency, the exact immunoregulatory role of iron is not known. Knowledge particularly in children, who are vulnerable to iron deficiency and infection, is lacking. We aimed to study the effects of IDA and its treatment with oral iron supplementation on cell-mediated immunity. The levels of T-lymphocytes, their CD4+, CD8+ and CD1a+ subsets, transferrin receptor (CD71) and serum ferritin were evaluated in 40 iron-deficient and 40 healthy children. The impact of oral iron supplementation for three months on the same parameters was also noted in children with IDA. The level of mature T-lymphocytes (CD4+ and CD8+) was significantly lower (P<0.001) while that of the immature T-cells (CD1a+) was significantly higher (p<0.001) in IDA children compared to the control. The mature T-cell count was significantly improved after iron therapy. In spite of significant reduction in the immature T-cells (CD1a+) level after iron supplementation, it was significantly higher than the control. The present study demonstrated that T-lymphocytes maturation was defective in IDA and improved partially after 3 months of iron supplementation. Therefore, longer time of iron therapy may be required to induce complete maturation of T-lymphocytes. © Indian Society of Haematology & Transfusion Medicine 2009.
Authors & Co-Authors
Attia Saad, Mohamed Saad
Egypt, Tanta
Faculty of Medicine
Essa, Salwa Abdel Moneim
Egypt, Tanta
Faculty of Medicine
Nosair, Nahla Abd El Azeez
Egypt, Tanta
Faculty of Medicine
Amin, Ahmed Mostafa
Egypt, Tanta
Faculty of Medicine
El-Agamy, Osama Abd Fattah
Egypt, Tanta
Faculty of Medicine
Statistics
Citations: 28
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1007/s12288-009-0017-3
ISSN:
09714502
Research Areas
Health System And Policy
Maternal And Child Health