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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Loss of leishmanin skin test antigen sensitivity and potency in a longitudinal study of visceral Leishmaniasis in Bangladesh
American Journal of Tropical Medicine and Hygiene, Volume 75, No. 4, Year 2006
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Description
Annual leishmanin skin test (LST) surveys were conducted in a visceral leishmaniasis-endemic Bangladeshi community from 2002 through 2004, using Leishmania infantum antigen from the same manufacturer and batch. In 2002, 530 (35%) of 1,532 had positive LST results; the prevalence increased with increasing age. The LST result was positive in 24 (51%) of 47, 18 (72%) of 25, and 11 (85%) of 13 kala-azar patients treated in the previous 1-11, 12-23, and 24-35 months. A positive LST result in 2002 was associated with protection against subsequent kala-azar (P < 0.0001). In 2003-2004, decreased antigen sensitivity was observed. Among 686 participants, 34% were LST-positive in 2002, 29% in 2003, and 19% in 2004. Of 63 cured kala-azar patients, 70% were positive in 2002, 53% in 2003, and only 30% in 2004. Among 171 participants tested with both antigens, L. infantum study antigen sensitivity was 70% compared with L. amazonensis antigen. Our data underscore the need for better production, standardization, and documentation of sensitivity, potency, and stability of leishmanin antigens. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Bern, Caryn
United States, Atlanta
Centers for Disease Control and Prevention
Amann, Josef
United States, Atlanta
Centers for Disease Control and Prevention
Haque, Rashidul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Chowdhury, Rajib Nayan
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Ali, Mustakim
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Kurkjian, Katie M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Vaz, Louise Elaine
United States, Nashville
Vanderbilt University
Wagatsuma, Yukiko
Japan, Tsukuba
University of Tsukuba
Breiman, Robert F.
United States, Atlanta
Centers for Disease Control and Prevention
Secor, William Evan
United States, Atlanta
Centers for Disease Control and Prevention
Maguire, James H.
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 44
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.4269/ajtmh.2006.75.744
ISSN:
00029637
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative