Solid-phase total synthesis of the pentacyclic system lamellarins U and L
Organic Letters, Volume 5, No. 16, Year 2003
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(Matrix presented) A total solid-phase synthesis of lamellarins U and L has been achieved. The conversion of an aldehyde group into a formate by a Baeyer-Villiger reaction and a intramolecular [3 + 2] cycloaddition of a 3,4-dihydroisoquinolinium salt over a triple bond comprise the key steps of the process. Each transformation has been controlled with the proper spectroscopic and analytical methods.