Pestalotiopamide E and pestalotiopin B from an endophytic fungus Aureobasidium pullulans isolated from Aloe vera leaves

A detailed chemical investigation of the mycelial extract of the endophytic fungus Aureobasidium pullulans isolated from leaves of the Moroccan Aloe vera yielded one new amide pestalotiopamide E (1) and its corresponding new acid pestalotiopin B (2) together with two indole metabolites (3 and 4), isoochracinic acid (5) and two hydronaphthalene derivatives (6 and 7). All isolated compounds were tested for their antiproliferative activity against mouse lymphoma L5178Y cell line.