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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human
Cancer Gene Therapy, Volume 15, No. 4, Year 2008
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Description
This paper highlights our experience of the transfer of hydrodynamic gene therapy (HGT) from the large animal, the pig, into clinical practice. The modification of balloon catheters and the development of a minimally invasive technique to allow selective isolation of liver segments for HGT in the large animal and human are described. Finally, our preliminary results from a phase I clinical study of HGT for thrombopoietin (TPO) in cirrhotic patients with thrombocytopenia are discussed. Based on these provisional data, minimally invasive selective HGT of liver segments appears to be technically safe, but further work is required to optimize the efficiency of gene transfer in order to achieve clinical benefit. © 2008 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Khorsandi, Shirin Elizabeth
United Kingdom, London
Imperial College London
Bachellier, Philippe
United Kingdom, London
Imperial College London
France, Strasbourg
Hopital de Hautepierre
Weber, Jean Christophe
United Kingdom, London
Imperial College London
France, Strasbourg
Hopital de Hautepierre
Greget, Michel C.
France, Strasbourg
Hopital de Hautepierre
Jaeck, Daniel
France, Strasbourg
Hopital de Hautepierre
Zacharoulis, Dimitris C.
Greece, Larissa
University of Larissa
Rountas, H. D.
Greece, Larissa
University of Larissa
Helmy, Salah
United Kingdom, London
Imperial College London
Egypt, Cairo
Faculty of Medicine
Helmy, Amr S.
Egypt, Cairo
Faculty of Medicine
Al-Waracky, M.
Egypt, Cairo
Faculty of Medicine
Salama, Hosny Mohamed
Egypt, Cairo
Faculty of Medicine
Jiao, Long
United Kingdom, London
Imperial College London
Nicholls, Joanna P.
United Kingdom, London
Imperial College London
Davies, A. J.
United Kingdom, London
Imperial College London
Levičar, Nataša Y.
United Kingdom, London
Imperial College London
Jensen, Steen Lindkaer
United Kingdom, London
Imperial College London
Habib, Nagy A.
United Kingdom, London
Imperial College London
United Kingdom, London
Hammersmith Hospital
Statistics
Citations: 17
Authors: 17
Affiliations: 5
Identifiers
Doi:
10.1038/sj.cgt.7701119
ISSN:
09291903
Research Areas
Genetics And Genomics