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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Incident cancer burden attributable to excess body mass index in 30 European countries
International Journal of Cancer, Volume 126, No. 3, Year 2010
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Description
Excess adiposity is associated with increased risks of developing adult malignancies. To inform public health policy and guide further research, the incident cancer burden attributable to excess body mass index (BMI ≥ 25 kg/m2) across 30 European countries were estimated. Population attributable risks (PARs) were calculated using European- and gender-specific risk estimates from a published meta-analysis and gender-specific mean BMI estimates from a World Health Organization Global Infobase. Country-specific numbers of new cancers were derived from Globocan2002. A ten-year lag-period between risk exposure and cancer incidence was assumed and 95% confidence intervals (CI) were estimated in Monte Carlo simulations. In 2002, there were 2,171,351 new all cancer diagnoses in the 30 countries of Europe. Estimated PARs were 2.5% (95% CI 1.5-3.6%) in men and 4.1% (2.3-5.9%) in women. These collectively corresponded to 70,288 (95% CI 40,069-100,668) new cases. Sensitivity analyses revealed estimates were most influenced by the assumed shape of the BMI distribution in the population and cancer-specific risk estimates. In a scenario analysis of a plausible contemporary (2008) population, the estimated PARs increased to 3.2% (2.1-4.3%) and 8.6% (5.6-11.5%), respectively, in men and women. Endometrial, post-menopausal breast and colorectal cancers accounted for 65% of these cancers. This analysis quantifies the burden of incident cancers attributable to excess BMI in Europe. The estimates reported here provide a baseline for future modelling, and underline the need for research into interventions to control weight in the context of endometrial, breast and colorectal cancer. © 2009 UICC.
Authors & Co-Authors
Renehan, Andrew G.
United Kingdom, Manchester
The University of Manchester
Soerjomataram, Isabelle
Netherlands, Rotterdam
Erasmus Mc
Egger, Matthias
Switzerland, Bern
University of Bern
United Kingdom, Bristol
University of Bristol
Zwahlen, Marcel
Switzerland, Bern
University of Bern
Coebergh, Jan Willem W.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Eindhoven
Integraal Kankercentrum Zuid
Buchan, Iain Edward
United Kingdom, Manchester
The University of Manchester
Statistics
Citations: 207
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1002/ijc.24803
ISSN:
10970215
Research Areas
Cancer
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review
Participants Gender
Male
Female