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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Ocular Fundus Findings in Malawian Children with Cerebral Malaria
Ophthalmology, Volume 100, No. 6, Year 1993
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Description
Background: Cerebral malaria is a major cause of mortality and morbidity in children in tropical regions. The pathogenesis of this important complication of Plasmodium falciparum infection is not well understood. A number of observers have commented on the presence of retinal pathology in various types of malaria. Previous reports have not demonstrated that fundus findings are significantly associated with outcome. Methods: The authors examined the ocular fundi, by direct and indirect ophthalmoscopy, of 56 children admitted consecutively with cerebral malaria. Results: Every child with a normal fundus on admission recovered fully, but two conditions were found to be associated with a poor outcome. Patients with papiiledema had a relative risk of poor outcome 5.2 times greater than those without this finding (P Ã 0.01). Patients with retinal edema outside the posterior vascular arcades had a relative risk of poor outcome 3.9 times greater than those without this finding (P Ã 0.01). These two fundus findings were independently predictive of a poor outcome. Conclusion: Fundus findings are useful as predictors of outcome in children with cerebral malaria. The authors' findings suggest that there may be two distinct mechanisms associated with poor outcome in these children. © 1993, American Academy of Ophthalmology, Inc. All rights reserved.
Authors & Co-Authors
Lewallen, Susan
Malawi
International Eye Foundation
Taylor, Terrie Ellen
United States, East Lansing
Msu College of Osteopathic Medicine
Molyneux, Malcolm Edward
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Wills, Bridget Ann
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Courtright, Paul D.
Malawi
International Eye Foundation
United Kingdom, London
International Centre for Eye Health
Statistics
Citations: 104
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/S0161-6420(93)31563-0
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health