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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Population relationships in the mediterranean revealed by autosomal genetic data (Alu and Alu/STR compound systems)
American Journal of Physical Anthropology, Volume 141, No. 3, Year 2010
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Description
The variation of 18 Alu polymorphisms and 3 linked STRs was determined in 1,831 individuals from 15 Mediterranean populations to analyze the relationships between human groups in this geographical region and provide a complementary perspective to information from studies based on uniparental markers. Patterns of population diversity revealed by the two kinds of markers examined were different from one another, likely in relation to their different mutation rates. Therefore, while the Alu biallelic variation underlies general heterogeneity throughout the whole Mediterranean region, the combined use of Alu and STR points to a considerable genetic differentiation between the two Mediterranean shores, presumably strengthened by a considerable sub-Saharan African genetic contribution in North Africa (around 13% calculated from Alu markers). Gene flow analysis confirms the permeability of the Sahara to human passage along with the existence of trans-Mediterranean interchanges. Two specific Alu/STR combinations - CD4 110(-) and DM 107(-) - detected in all North African samples, the Iberian Peninsula, Greece, Turkey, and some Mediterranean islands suggest an ancient genetic background of current Mediterranean peoples. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
González-Pérez, Emili
Spain, Barcelona
Universitat de Barcelona
Esteban, Esther M.
Spain, Barcelona
Universitat de Barcelona
Via, Marc
Spain, Barcelona
Universitat de Barcelona
United States, San Francisco
Ucsf School of Medicine
United States, San Francisco
University of California, San Francisco
Gayà-Vidal, Magdalena
Spain, Barcelona
Universitat de Barcelona
Athanasiadis, Georgios
Spain, Barcelona
Universitat de Barcelona
Dugoujon, Jean Michel H.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Luna, Francisco
Spain, Madrid
Universidad Complutense de Madrid
Mesa, Maria Soledad
Spain, Madrid
Universidad Complutense de Madrid
Fuster, Vicente
Spain, Madrid
Universidad Complutense de Madrid
Kandil, Mostafa
Morocco, El Jadida
Faculté Des Sciences D'el Jadida
Harich, Nourdin
Morocco, El Jadida
Faculté Des Sciences D'el Jadida
Bissar-Tadmouri, Nisrine
United Arab Emirates, Sharjah
College of Medicine
Saetta, Angela
Greece, Athens
School of Medicine
Moral, Pedro
Spain, Barcelona
Universitat de Barcelona
Statistics
Citations: 46
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1002/ajpa.21161
ISSN:
00029483
e-ISSN:
10968644
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Multi-countries