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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Normal spermatogenesis in a man with mutant luteinizing hormone
New England Journal of Medicine, Volume 361, No. 19, Year 2009
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Description
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells. We report a mutation in LHB in a man and his sister. The man presented with absence of virilization, undetectable luteinizing hormone, and a low serum testosterone level. He had complete spermatogenesis with a normal sperm count. The mutant luteinizing hormone had a low level of partial activity in vitro. We concluded that the residual luteinizing hormone activity, resulting in the expression of steroidogenic enzymes in few mature Leydig cells producing small amounts of intratesticular testosterone (20.2 ng per gram), was sufficient for complete and quantitatively normal spermatogenesis. Copyright © 2009 Massachusetts Medical Society. All rights reserved.
Authors & Co-Authors
Achard, Caroline Stephanie
France, Paris
Inserm
Courtillot, Carine
France, Paris
Sorbonne Université
Lahuna, Olivier
France, Paris
Inserm
France, Paris
Université Paris Cité
Méduri, Géri
France, Le Kremlin-bicetre
Hopital de Bicetre
Soufir, Jean Claude
France, Le Kremlin-bicetre
Hopital de Bicetre
France, Paris
Université Paris Cité
Lière, Philippe
France, Le Kremlin-bicetre
Hopital de Bicetre
Bachelot, Anne
France, Paris
Sorbonne Université
Benyounes, Hassani
Morocco, Oujda
Abdou Hay al Mahatta
Schumacher, Michaël
France, Le Kremlin-bicetre
Hopital de Bicetre
Kuttenn, Frédéarique
France, Paris
Sorbonne Université
Touraine, Philippe A.
France, Paris
Sorbonne Université
Misrahi, Micheline
France, Paris
Inserm
France, Le Kremlin-bicetre
Hopital de Bicetre
France, Paris
Université Paris Cité
Statistics
Citations: 61
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1056/NEJMoa0805792
ISSN:
00284793
e-ISSN:
15334406
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Male