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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile
BMC Immunology, Volume 8, Article 29, Year 2007
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Description
Background: CD146 is a well described homotypic adhesion molecule found on endothelial cells and a limited number of other cell types. In cells from the peripheral circulation, CD146 has also been reported to be on activated lymphocytes in vitro and in vivo. The function associated with CD146 expression on lymphoid cells is unknown and very little information is available concerning the nature of CD146+ lymphocytes. In the current study, lymphocytes from healthy donors were characterized based upon the presence or absence of CD146 expression. Results: CD146 was expressed on a low percentage of circulating T lymphocytes, B lymphocytes, and NK cells in healthy individuals. CD146 expression can be induced and upregulated in vitro on both B cells and T cells, but does not correlate with the expression of other markers of T cell activation. CD146 positive T cells do not represent clonal expansions as determined with the use of anti Vβ reagents. Data suggest that CD146 positive cells have enhanced adherence to endothelial monolayers in vitro. Gene profiling and immunophenotyping studies between CD146+ and CD146- T cells revealed several striking genotypic distinctions such as the upregulation of IL-8 and phenotypic differences including the paucity of CCR7 and CD45RA among CD146 positive T cells, consistent with effector memory function. A number of genes involved in cell adhesion, signal transduction, and cell communication are dramatically upregulated in CD146+ T cells compared to CD146- T cells. Conclusion: CD146 appears to identify small, unique populations of T as well as B lymphocytes in the circulation. The T cells have immunophenotypic characteristics of effector memory lymphocytes. The characteristics of these CD146+ lymphocytes in the circulation, together with the known functions in cell adhesion of CD146 on endothelial cells, suggests that these lymphocytes may represent a small subpopulation of cells primed to adhere to the endothelium and possibly extravasate to sites of inflammation. © 2007 Elshal et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Elshal, Mohamed Farouk
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Egypt, Shibin el Kom
Menoufia University
Khan, Sameena S.
United States, Bethesda
National Institutes of Health Nih
Raghavachari, Nalini
United States, Bethesda
National Institutes of Health Nih
Takahashi, Yoshiyuki
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Barb, Jennifer Joanna
United States, Not-specified
Center for Information Technology
Bailey, James J.
United States, Not-specified
Center for Information Technology
Munson, Peter Jonathan
United States, Not-specified
Center for Information Technology
Solomon, Michael A.
United States, Bethesda
National Institutes of Health Nih
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Danner, Robert L.
United States, Bethesda
National Institutes of Health Nih
McCoy, J. Philip
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Statistics
Citations: 10
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1186/1471-2172-8-29
e-ISSN:
14712172
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study