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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Contrasting signatures of population growth for mitochondrial DNA and Y chromosomes among human populations in Africa
Molecular Biology and Evolution, Volume 25, No. 3, Year 2008
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Description
A history of Pleistocene population expansion has been inferred from the frequency spectrum of polymorphism in the mitochondrial DNA (mtDNA) of many human populations. Similar patterns are not typically observed for autosomal and X-linked loci. One explanation for this discrepancy is a recent population bottleneck, with different rates of recovery for haploid and autosomal loci as a result of their different effective population sizes. This hypothesis predicts that mitochondrial and Y chromosomal DNA will show a similar skew in the frequency spectrum in populations that have experienced a recent increase in effective population size. We test this hypothesis by resequencing 6.6 kb of noncoding Y chromosomal DNA and 780 basepairs of the mtDNA cytochrome c oxidase subunit III (COIII) gene in 172 males from 5 African populations. Four tests of population expansion are employed for each locus in each population: Fu's Fs statistic, the R2 statistic, coalescent simulations, and the mismatch distribution. Consistent with previous results, patterns of mtDNA polymorphism better fit a model of constant population size for food-gathering populations and a model of population expansion for food-producing populations. In contrast, none of the tests reveal evidence of Y chromosome growth for either food-gatherers or food-producers. The distinct mtDNA and Y chromosome polymorphism patterns most likely reflect sex-biased demographic processes in the recent history of African populations. We hypothesize that males experienced smaller effective population sizes and/or lower rates of migration during the Bantu expansion, which occurred over the last 5,000 years. © The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.
Authors & Co-Authors
Pilkington, Maya Metni
United States, Tucson
The University of Arizona
Wilder, Jason A.
United States, Tucson
Arizona Research Laboratories
United States, Williamstown
Williams College
Mendez, Fernando L.
United States, Tucson
The University of Arizona
Cox, Murray P.
United States, Tucson
Arizona Research Laboratories
Woerner, August E.
United States, Tucson
Arizona Research Laboratories
Angui, Thiep
United States, Tucson
Arizona Research Laboratories
Kingan, Sarah B.
United States, Tucson
Arizona Research Laboratories
Mobasher, Zahra
United States, Tucson
Arizona Research Laboratories
Batini, Chiara
Italy, Rome
Sapienza Università Di Roma
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Destro Bisol, Giovanni Giovanni
Italy, Rome
Sapienza Università Di Roma
Italy, Rome
Istituto Italiano Di Antropologia
Soodyall, Himla
South Africa, Johannesburg
University of the Witwatersrand
Strassmann, Beverly Ilse
United States, Ann Arbor
University of Michigan, Ann Arbor
Hammer, Michael F.
United States, Tucson
The University of Arizona
United States, Tucson
Arizona Research Laboratories
Statistics
Citations: 54
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1093/molbev/msm279
ISSN:
07374038
e-ISSN:
15371719
Research Areas
Food Security
Genetics And Genomics
Study Design
Cross Sectional Study