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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: Predominance of evolving relationships
PLoS ONE, Volume 5, No. 3, Article e9629, Year 2010
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Description
Background: During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable quantitative trait that has clinical and epidemiological implications. Immunogenetic research has established various human genetic factors, especially human leukocyte antigen (HLA) variants, as independent determinants of VL set-point. Methodology/Principal Findings: To identify and clarify HLA alleles that are associated with either transient or durable immune control of HIV-1 infection, we evaluated the relationships of HLA class I and class II alleles with VL among 563 seroprevalent Zambians (SPs) who were seropositive at enrollment and 221 seroconverters (SCs) who became seropositive during quarterly follow-up visits. After statistical adjustments for non-genetic factors (sex and age), two unfavorable alleles (A*3601 and DRB1*0102) were independently associated with high VL in SPs (p<0.01) but not in SCs. In contrast, favorable HLA variants, mainly A*74, B*13, B*57 (or Cw*18), and one HLA-A and HLA-C combination (A*30+Cw*03), dominated in SCs; their independent associations with low VL were reflected in regression beta estimates that ranged from - 0.47±0.23 to 20.9260.32 log10 in SCs (p<0.05). Except for Cw*18, all favorable variants had diminishing or vanishing association with VL in SPs (p≤0.86). Conclusions/Significance: Overall, each of the three HLA class I genes had at least one allele that might contribute to effective immune control, especially during the early course of HIV-1 infection. These observations can provide a useful framework for ongoing analyses of viral mutations induced by protective immune responses. © 2010 Tang et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2835758/bin/pone.0009629.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2835758/bin/pone.0009629.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2835758/bin/pone.0009629.s003.doc
Authors & Co-Authors
Tang, Jianming
United States, Birmingham
The University of Alabama at Birmingham
Malhotra, Rakhi
United States, Birmingham
The University of Alabama at Birmingham
Song, Wei
United States, Birmingham
The University of Alabama at Birmingham
Brill, Ilene K.
United States, Birmingham
The University of Alabama at Birmingham
Hu, Liangyuan
United States, Birmingham
The University of Alabama at Birmingham
Farmer, Paul K.
United States, Atlanta
Emory University
Mulenga, Joseph
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
Allen, Susan A.
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
United States, Atlanta
Emory University
Hunter, Eric
United States, Atlanta
Emory University
Kaslow, Richard A.
United States, Birmingham
The University of Alabama at Birmingham
Statistics
Citations: 47
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0009629
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative