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Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation

Cell Reports, Volume 31, No. 2, Article 107496, Year 2020

A preovulatory LH surge induces the expression of PGR and the production of PGE2, a proinflammatory prostaglandin, in preovulatory granulosa cells. Park et al. show that PGR then suppresses PGE2 synthesis by decreasing the expression of PTGS2. Such PGR-driven termination temporarily confines ovulatory inflammation within a short period.

Park, Chan-jin
1. United States, Urbana University of Illinois Urbana-champaign
Lin, Poching
1. United States, Urbana University of Illinois Urbana-champaign
Zhou, Sherry
1. United States, Urbana University of Illinois Urbana-champaign
Barakat, Radwa Abdelrazik
1. United States, Urbana University of Illinois Urbana-champaign
2. Egypt, Benha Faculty of Veterinary Medicine Benha University
Bashir, Shah Tauseef
1. United States, Urbana University of Illinois Urbana-champaign
Choi, Jeongmoon
1. United States, Urbana University of Illinois Urbana-champaign
Cacioppo, Joseph A.
1. United States, Urbana University of Illinois Urbana-champaign
Oakley, Oliver R.
1. United States, Richmond Eastern Kentucky University
Duffy, Diane M.
1. United States, Norfolk Eastern Virginia Medical School
Lydon, John P.
1. United States, Houston Baylor College of Medicine
Ko, Chemyong Jay
1. United States, Urbana University of Illinois Urbana-champaign

AFRICAN RESEARCH NEXUS

Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation

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AFRICAN RESEARCH NEXUS

Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation

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African Research Nexus

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