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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Human parvovirus B19 infection in sickle cell anemia patient in Mali: A case-control study
Archives de Pediatrie, Volume 18, No. 9, Year 2011
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Description
Human parvovirus B19 (HP-19) is the only Parvoviridae known to be pathogenic in human. Studies of HP-19 infection and its associated life-threatening complications in sickle cell anemia patients have been reported in Europe and the US. These results justify the development of HP-B19 prevention and strategies to reduce the incidence of severe and life-threatening complications associated with the infection in patients with sickle cell anemia, particularly in sub-Saharan Africa where the sickle cell anemia burden is high. In light of these considerations, we conducted a case-control study including 163 patients with sickle cell anemia and 163 controls. HP-B19 diagnosis was based on the detection of IgG and IgM antibodies specific for HP-B19 using commercially available enzyme immunoassays. Anti-human parvovirus B19 IgG antibodies were found in 105 of 193 (64.8%) patients vs 79 of 193 controls (48.4%). IgM antibodies were found at a higher frequency in sickle cell anemia patients than in controls. This higher frequency was found to be age-dependent. However, the reticulocyte count showed no significant decrease in Malian patients with sickle cell anemia. Further studies are needed to better characterize the implication of HP-B19 infection in sickle cell anemia mortality and morbidity and to develop preventive strategies and efficient management of the resulting complications. © 2011.
Authors & Co-Authors
Diallo, Dapa Aly
Mali, Bamako
Centre de Recherche et de Lutte Contre la Drépanocytose Crld
Mali, Bamako
Chu Point g
Guindo, Aldiouma
Mali, Bamako
Centre de Recherche et de Lutte Contre la Drépanocytose Crld
Dorie, A.
Mali, Bamako
Centre de Recherche et de Lutte Contre la Drépanocytose Crld
Djibo, Nagirou
Mali, Bamako
Laboratoire Mérieux
Algiman, Etienne
Mali, Bamako
Laboratoire D´analyses Médicales Algi
Ouane, Oumahane Diallo
Mali, Bamako
Centre Hospitalier Universitaire Mère-enfant Chume
Diakité, Abdoul Aziz
Mali, Bamako
Chu Gabriel-touré
Traoré, Fousséni F.
Mali, Bamako
Laboratoire Mérieux
Ag Baraika, M.
Mali, Bamako
Centre de Recherche et de Lutte Contre la Drépanocytose Crld
Dembélé, Abdoul Karim
Mali, Bamako
Chu Point g
Tchernia, Gilbert
Mali, Bamako
Centre de Recherche et de Lutte Contre la Drépanocytose Crld
Statistics
Citations: 11
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1016/j.arcped.2011.06.019
ISSN:
0929693X
e-ISSN:
1769664X
Research Areas
Health System And Policy
Study Design
Cohort Study
Case-Control Study
Study Locations
Mali