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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Effect of thalidomide on the expression of TNF-α m-RNA and synthesis of TNF-α in cells from leprosy patients with reversal reaction
Immunopharmacology and Immunotoxicology, Volume 28, No. 3, Year 2006
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Description
Hypersensitivity reactions called reversal reaction (RR) and erythema nodosum leprosum (ENL) occur in leprosy. They are characterized by an increase in tumor necrosis factor-alpha (TNF-α). Thalidomide is an effective treatment for ENL but not RR. Its effectiveness in ENL is attributed to inhibition of TNF-α, and this does not explain its failure to treat RR. We assessed thalidomide's effect on TNF-α in RR. Mononuclear cells from RR and non-RR patients and healthy individuals were treated with thalidomide and M.leprae (AFB), a cytosol fraction of M. leprae or Dharmendra lepromin. Thalidomide suppressed TNF-α, but when some RR patients' cells were stimulated with AFB, it enhanced TNF-α. Copyright © Informa Healthcare.
Authors & Co-Authors
Tadesse, Azeb
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
United States, Baton Rouge
School of Veterinary Medicine
United States, Baton Rouge
Louisiana State University
United States, New York
Icahn School of Medicine at Mount Sinai
Abebe, Markos
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Bizuneh, Elizabeth
Ethiopia, Addis Ababa
All Africa Leprosy, Tuberculosis and Rehabilitation Training Centre Addis Ababa
Mulugeta, Wondwossen
Ethiopia, Addis Ababa
All Africa Leprosy, Tuberculosis and Rehabilitation Training Centre Addis Ababa
Aseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Shannon, Edward Joseph
United States, Baton Rouge
Louisiana State University
Statistics
Citations: 13
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1080/08923970600928023
ISSN:
08923973
e-ISSN:
15322513
Research Areas
Cancer
Health System And Policy