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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas
Journal of Infectious Diseases, Volume 208, No. 3, Year 2013
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Description
Background. GMZ2 is a hybrid protein consisting of the N-terminal region of the glutamate-rich protein fused in frame to the C-terminal region of merozoite surface protein 3 (MSP3). GMZ2 formulated in Al(OH)3 has been tested in 3 published phase 1 clinical trials. The GMZ2/alum formulation showed good safety, tolerability, and immunogenicity, but whether antibodies elicited by vaccination are functional is not known.Methods. Serum samples prior to vaccination and 4 weeks after the last vaccination from the 3 clinical trials were used to perform a comparative assessment of biological activity against Plasmodium falciparum.Results. We showed that the maximum level of immunoglobulin G (IgG) antibodies obtained by GMZ2 vaccination is independent of ethnicity, time under malaria-exposure, and vaccine dose and that GMZ2 elicits high levels of functionally active IgG antibodies. Both, malaria-naive adults and malaria-exposed preschool children elicit vaccine-specific antibodies with broad inhibitory activity against geographically diverse P. falciparum isolates. Peptide-mapping studies of IgG subclass responses identified IgG3 against a peptide derived from MSP3 as the strongest predictor of antibody-dependent cellular inhibition.Conclusions. These findings suggest that GMZ2 adjuvanted in Al(OH)3 elicits high levels of specific and functional antibodies with the capacity to control parasite multiplication. © 2013 The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Jepsen, Micha Phill Grønholm
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Jogdand, Prajakta S.
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Singh, Susheel Kumar
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Esen, Meral
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Centre de Recherches Médicales de Lambaréné
Christiansen, Michael
Denmark, Copenhagen
Statens Serum Institut
Issifou, Saadou
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Centre de Recherches Médicales de Lambaréné
Hounkpatin, Aurore Bouyoukou
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Centre de Recherches Médicales de Lambaréné
Ateba-Ngoa, Ulysse
Gabon, Lambarene
Centre de Recherches Médicales de Lambaréné
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Centre de Recherches Médicales de Lambaréné
Dziegiel, Morten Hanefeld H.
Denmark, Copenhagen
Rigshospitalet
Olesen-Larsen, Severin
Denmark, Copenhagen
Statens Serum Institut
Jepsen, Sören B.
Denmark, Copenhagen
Statens Serum Institut
Mordmüller, Benjamin G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Centre de Recherches Médicales de Lambaréné
Theisen, Michael
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Statistics
Citations: 71
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/jit185
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health