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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family
Genomics, Volume 72, No. 1, Year 2001
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Description
The SLC26 gene family (solute carrier family 26) comprises five mammalian genes that encode anion transporter-related proteins. In addition to sat-1 and prestin, which were cloned from rat and gerbil, respectively, three human members have been identified and associated with specific genetic diseases (DTD, diastrophic dysplasia; CLD, congenital chloride diarrhea; PDS, Pendred syndrome). In this study we used a homology approach combined with RACE PCR to identify human SLC26A6, the sixth member of this gene family. Northern blot analysis showed the highest SLC26A6 transcript levels in kidney and pancreas. Expression in MDCK cells and in Xenopus oocytes demonstrated trafficking of the SLC26A6 protein to the cell membrane but did not reveal anion transport activity with tracer uptake or intracellular pH measurements. We determined the genomic structure of the SLC26A6 gene and excluded mutations in the 21 coding exons as the cause of DFNB6 and USH2B, which closely map to the SLC26A6 chromosomal locus (3p21). © 2001 Academic Press.
Authors & Co-Authors
Waldegger, Siegfried
Germany, Marburg
Philipps-universität Marburg
Moschen, Ivano
Germany, Tubingen
Eberhard Karls Universität Tübingen
Ramírez, Alfredo Echevarria
Germany, Bonn
Universität Bonn
Smith, Richard J.H.
United States, Iowa City
University of Iowa
Ayadi, Hammadi
Tunisia, Sfax
Faculty of Medicine of Sfax
Lang, Florian C.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kubisch, Christian
Germany, Bonn
Universität Bonn
Statistics
Citations: 87
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1006/geno.2000.6445
ISSN:
08887543
Research Areas
Genetics And Genomics