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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Emergence of epidemic neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso
PLoS ONE, Volume 6, No. 5, Article e19513, Year 2011
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Description
Serogroup X meningococci (NmX) historically have caused sporadic and clustered meningitis cases in sub-Saharan Africa. To study recent NmX epidemiology, we analyzed data from population-based, sentinel and passive surveillance, and outbreak investigations of bacterial meningitis in Togo and Burkina Faso during 2006-2010. Cerebrospinal fluid specimens were analyzed by PCR. In Togo during 2006-2009, NmX accounted for 16% of the 702 confirmed bacterial meningitis cases. Kozah district experienced an NmX outbreak in March 2007 with an NmX seasonal cumulative incidence of 33/100,000. In Burkina Faso during 2007-2010, NmX accounted for 7% of the 778 confirmed bacterial meningitis cases, with an increase from 2009 to 2010 (4% to 35% of all confirmed cases, respectively). In 2010, NmX epidemics occurred in northern and central regions of Burkina Faso; the highest district cumulative incidence of NmX was estimated as 130/100,000 during March-April. Although limited to a few districts, we have documented NmX meningitis epidemics occurring with a seasonal incidence previously only reported in the meningitis belt for NmW135 and NmA, which argues for development of an NmX vaccine. © 2011 Delrieu et al.
Authors & Co-Authors
Delrieu, Isabelle
France, Paris
Agence de Médecine Préventive
Yaro, Seydou
Burkina Faso, Ouagadougou
Centre Muraz
Tamekloé, Tsidi Agbeko S.
Togo, Lome
Ministry of Health
Njanpop-Lafourcade, Berthe Marie
France, Paris
Agence de Médecine Préventive
Tall, Haoua
France, Paris
Agence de Médecine Préventive
Jaillard, Philippe
France, Paris
Agence de Médecine Préventive
Ouédraogo, Macaire Sampawendé
Burkina Faso, Bobo-dioulasso
Centre Hospitalier Universitaire Souro Sanou
Badziklou, Kossi
Togo, Lome
Institut National de L'hygiène
Sanou, Oumarou
France, Paris
Agence de Médecine Préventive
Drabo, Aly
Burkina Faso, Ouagadougou
Centre Muraz
Gessner, Bradford D.
France, Paris
Agence de Médecine Préventive
Kambou, Jean Ludovic
Burkina Faso, Ouagadougou
Ministere de la Sante Ouagadougou
Mueller, Judith E.
France, Paris
Agence de Médecine Préventive
Statistics
Citations: 119
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0019513
e-ISSN:
19326203
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Burkina Faso
Togo