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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study
The Lancet Gastroenterology and Hepatology, Volume 3, No. 6, Year 2018
Notification
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Description
Background: The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate viral hepatitis by 2030. Although no virological cure exists for hepatitis B virus (HBV) infection, existing therapies to control viral replication and prophylaxis to minimise mother-to-child transmission make elimination of HBV feasible. We aimed to estimate the national, regional, and global prevalence of HBsAg in the general population and in the population aged 5 years in 2016, as well as coverage of prophylaxis, diagnosis, and treatment. Methods: In this modelling study, we used a Delphi process that included a literature review in PubMed and Embase, followed by interviews with experts, to quantify the historical epidemiology of HBV infection. We then used a dynamic HBV transmission and progression model to estimate the country-level and regional-level prevalence of HBsAg in 2016 and the effect of prophylaxis and treatment on disease burden. Findings: We developed models for 120 countries, 78 of which were populated with data approved by experts. Using these models, we estimated that the global prevalence of HBsAg in 2016 was 3·9% (95% uncertainty interval [UI] 3·4–4·6), corresponding to 291 992 000 (251 513 000–341 114 000) infections. Of these infections, around 29 million (10%) were diagnosed, and only 4·8 million (5%) of 94 million individuals eligible for treatment actually received antiviral therapy. Around 1·8 (1·6–2·2) million infections were in children aged 5 years, with a prevalence of 1·4% (1·2–1·6). We estimated that 87% of infants had received the three-dose HBV vaccination in the first year of life, 46% had received timely birth-dose vaccination, and 13% had received hepatitis B immunoglobulin along with the full vaccination regimen. Less than 1% of mothers with a high viral load had received antiviral therapy to reduce mother-to-child transmission. Interpretation: Our estimate of HBV prevalence in 2016 differs from previous studies, potentially because we took into account the effect of infant prophylaxis and early childhood vaccination, as well as changing prevalence over time. Although some regions are well on their way to meeting prophylaxis and prevalence targets, all regions must substantially scale-up access to diagnosis and treatment to meet the global targets. Funding: John C Martin Foundation. © 2018 Elsevier Ltd
Authors & Co-Authors
Razavi-Shearer, Devin
United States, Lafayette
Cda Foundation
Gamkrelidze, Ivane
United States, Lafayette
Cda Foundation
Nguyen, Mindie H.
United States, Stanford
Stanford Healthcare
CHEN, DING SHINN
Taiwan, Taipei
National Taiwan University Hospital
Taiwan, Taipei
National Taiwan University College of Medicine
Van-Damme, Pierre A.
Belgium, Antwerpen
Universiteit Antwerpen
Abbas, Zaigham
Pakistan, Karachi
Ziauddin University
Abdulla, Maheeba A.M.
Bahrain, Manama
Ministry of Health, Kingdom of Bahrain
Abou Rached, Antoine
Lebanon, Beirut
Ministry of Public Health, Lebanon
Adda, Danjuma
Nigeria, Abuja
Civil Society Network on Hepatitis
Nigeria
Chagro-care Trust
Aho, Inka
Finland, Helsinki
Helsinki University Hospital
Akarca, Ulus Salih
Turkey, Izmir
Ege Üniversitesi
al-Ali, Fuad Hasan
Kuwait, Kuwait City
Kuwait University
Lawati, Faryal Al
Oman, Muscat
Ministry of Health Oman
Naamani, Khalid Al
Oman, Muscat
Armed Forces Hospital
Alashgar, Hamad Ibrahim
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Alavian, Seyed Moayed
Iran, Tehran
Baqiyatallah University of Medical Sciences
Iran, Tehran
Middle East Liver Diseases Meld Center
Al-Awadhi, Sameer A.
United Arab Emirates, Dubai
Rashid Hospital
Albillos, Agustín
Spain, Madrid
Instituto Ramón y Cajal de Investigación Sanitaria
Spain, Madrid
Hospital Universitario Ramón y Cajal
Al-Busafi, Said A.
Oman, Muscat
Sultan Qaboos University Hospital
Aleman, Soo
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Karolinska Universitetssjukhuset
Al-Faleh, Faleh Zaid
Saudi Arabia, Riyadh
King Saud University
Aljumah, Abdulrahman A.
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Anand, Anil C.
India, New Delhi
Indraprastha Apollo Hospitals
Nguyen, Thu Anh
Australia, Sydney
The University of Sydney
Arends, Joop E.A.
Netherlands, Utrecht
Universiteit Utrecht
Arkkila, Perttu E.T.
Finland, Helsinki
Helsinki University Hospital
Athanasakis, Kostas P.
Greece, Athens
National School of Public Health
Bane, Abate
Ethiopia, Addis Ababa
Addis Ababa University
Ethiopia, Addis Ababa
Ethiopian Medical Association
Ben-Ari, Ziv
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Berg, Thomas
Germany, Leipzig
Universität Leipzig
Bizri, Abdul Rahman N.
Lebanon, Beirut
American University of Beirut
Blach, Sarah
United States, Lafayette
Cda Foundation
Brandão-Mello, Carlos Eduardo
Brazil, Rio de Janeiro
Universidade Federal do Estado do Rio de Janeiro
Brandon, Samantha M.
United States, Lafayette
Cda Foundation
Bright, Bisi
Nigeria, Lagos
Livewell Initiative Lwi
Bruggmann, Philip
Switzerland, Zurich
Arud Centres for Addiction Medicine
Brunetto, M. R.
Italy, Pisa
Università Di Pisa
Butí, María Asunción
Spain, Barcelona
Hospital Universitari Vall D'hebron
Chan, Henry Lik Yuen
Hong Kong, Hong Kong
Chinese University of Hong Kong
Chaudhry, Asad Ali
Pakistan, Gujranwala
Siddiq Sadiq Hospital
Chien, Rongnan
Taiwan, Taipei
Chang Gung Memorial Hospital
Choi, Moon-seok
South Korea, Seoul
Samsung Medical Center, Sungkyunkwan University
Christensen, Peer Brehm
Denmark, Odense
Odense Universitetshospital
Chuang, Wan–Long
Taiwan, Kaohsiung
Kaohsiung Medical University
Chulanov, Vladimir P.
Russian Federation, Moscow
Central Research Institute of Epidemiology
Russian Federation, Moscow
Sechenov First Moscow State Medical University
Clausen, Mette Rye
Denmark, Copenhagen
Rigshospitalet
Colombo, Massimo Giuseppe
Italy, Rozzano
Clinical and Research Center Humanitas
Cornberg, Markus
Germany, Hannover
Hannover Medical School
Germany, Hannover
German Research Foundation
Cowie, Benjamin C.
Australia, Canberra
World Health Organization, Australia
Craxi, Antonio
Italy, Palermo
Università Degli Studi Di Palermo
Italy, Palermo
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Croes, Esther A.
Netherlands, Utrecht
Trimbos Institute, Netherlands Institute of Mental Health and Addiction
Cuellar, Diego Alberto
Colombia, Bogota
Ministry of Health and Social Protection
Cunningham, Chris W.
New Zealand, Wellington
Massey University Wellington
Desalegn, Hailemichael M.
Ethiopia, Addis Ababa
St. Paul‘s Hospital Millennium Medical College
Dražilová, Sylvia
Slovakia
Hospital Poprad
Duberg, Ann Sofi
Sweden, Orebro
Örebro Universitet
Egeonu, Steve S.
Nigeria
Federal Medical Centre Nigeria
El-Sayed, Manal Hamdy
Egypt, Cairo
Ain Shams University
Estes, Chris R.
United States, Lafayette
Cda Foundation
Falconer, Karolin
Sweden, Stockholm
Karolinska Institutet
Ferraz, Maria Lucia Gomes Lúcia Gomes
Brazil, Sao Paulo
Universidade Federal de São Paulo
Ferreira, Paulo Roberto Abrão
Brazil, Sao Paulo
Universidade Federal de São Paulo
Flisiak, Robert
Poland, Bialystok
Uniwersytet Medyczny w Bialymstoku
Fraňková, Soňa
Czech Republic, Prague
Institutu Klinické a Experimentální Medicíny
Gaeta, Giovanni Battista
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
García-Samaniego, Javier
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
Genov, Jordan
Bulgaria, Sofia
University Hospital 'queen Giovanna '
Gerstoft, Jan
Denmark, Copenhagen
Københavns Universitet
Goldiş, Adrian Eugen
Romania, Timisoara
Universitatea de Medicina si Farmacie Victor Babes Din Timisoara
Gountas, Ilias
United States, Louisville
Center for Disease Analysis
Gray, Richard Thomas
Australia, Sydney
Unsw Sydney
Pessoa, Mário Guimarães
Brazil, Sao Paulo
Universidade de São Paulo
Hajarizadeh, Behzad
Australia, Sydney
Unsw Sydney
Hatzakis, Angelos E.
Greece, Athens
School of Medicine
Greece, Athens
Hellenic Scientific Society for the Study of Aids and Sexually Transmitted Diseases
Heźode, Christophe
France, Creteil
Hôpital Henri Mondor
Himatt, Sayed
Qatar, Doha
Ministry of Public Health Qatar
Hoepelman, Andy I.M.
Unknown Affiliation
Hrstić, Irena
Croatia, Pula
General Hospital Pula
Hui, Yee Tak T.
China, Hong Kong
Queen Elizabeth Hospital Hong Kong
Husa, Petr
Czech Republic, Brno
Masaryk University
Jahis, Rohani
Malaysia, Putrajaya
Kementerian Kesihatan Malaysia
Janjua, Naveed Z.
Canada, Vancouver
Bc Centre for Disease Control
Canada, Vancouver
The University of British Columbia
Jarčuška, Peter
Slovakia, Kosice
Pavol Jozef Šafárik University in Košice
Jaroszewicz, Jerzy
Poland, Katowice
Slaski Uniwersytet Medyczny w Katowicach
Kaymakoĝlu, Sabahattin
Turkey, Istanbul
Istanbul Üniversitesi
Kershenobich-Stalnikowitz, David D.
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Kondili, Loreta Anesti
Italy, Rome
Istituto Superiore Di Sanita
Konysbekova, Aliya
Kazakhstan, Astana
Republican Diagnostic Center
Kazakhstan, Astana
University Medical Center
Krajden, Mel
Canada, Vancouver
Bc Centre for Disease Control
Canada, Vancouver
The University of British Columbia
Kristian, Pavol
Slovakia, Kosice
Pavol Jozef Šafárik University in Košice
Laleman, Wim J.
Belgium, Leuven
Ku Leuven
Lao, Wai Cheung C.
China, Hong Kong
Pamela Youde Nethersole Eastern Hospital
Layden, Jennifer E.
United States, Chicago
Loyola University Chicago
Lazarus, J. V.
Denmark, Copenhagen
Rigshospitalet
Spain, Barcelona
Instituto de Salud Global de Barcelona
Lee, Meihsuan
Taiwan, Taipei
National Yang-ming University Taiwan
Liakina, Valentina
Lithuania, Vilnius
Vilniaus Universitetas
Lim, Young Suk
South Korea, Seoul
Asan Medical Center
Loo, Ching Kong K.
Uganda, Kampala
Makerere University
Lukic, Boris
Croatia, Split
Klinički Bolnički Centar Split
Malekzadeh, Reza
Iran, Tehran
Tehran University of Medical Sciences
Malu, Abraham O.
Nigeria, Makurdi
Benue State University
Manns, Michael Peter
Germany, Hannover
Hannover Medical School
Marinho, Rui Tato
Portugal, Lisbon
Santa Maria Hospital, Lisbon
Matičič, Mojca
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Memon, Muhammad Sadik
Unknown Affiliation
Mendes-Corrěa, Maria Cássia Jacintho
Brazil, Sao Paulo
Universidade de São Paulo
Méndez-Sánchez, Nahúm
Mexico, Mexico
Fundacion Clinica Medica Sur
Merat, Shahin
Iran, Tehran
Tehran University of Medical Sciences
Metwally, Ammal M.
Egypt, Giza
National Research Centre
Mohamed, Rosmawati Binti
Malaysia, Kuala Lumpur
University of Malaya Medical Centre
Mokhbat, Jacques Emile
Lebanon, Beirut
Lebanese American University Medical Center-rizk Hospital
Moreno, Christophe
Belgium, Brussels
Université Libre de Bruxelles
Mossong, Joël R.
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Mourad, Fadi H.
Lebanon, Beirut
American University of Beirut
Mul̈lhaupt, Beat
Switzerland, Zurich
Universitatsspital Zurich
Murphy, Kimberly
United States, Lafayette
Cda Foundation
Nawaz, Arif Amir
Pakistan, Lahore
Fatima Memorial Hospital
Nde, Helen M.
United States, Lafayette
Cda Foundation
Negro, Francesco
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Nersesov, Alexander V.
Kazakhstan, Almaty
Scientific and Research Institute of Cardiology and Internal Diseases
Njouom, Richard
Cameroon, Yaounde
Centre Pasteur du Cameroun
Ntagirabiri, Rénovat
Unknown Affiliation
Nurmatov, Zuridin Sh
Kyrgyzstan, Bishkek
Ministry of Health of the Kyrgyz Republic
Obekpa, Solomon A.
Nigeria, Makurdi
Benue State University
Ocama, Ponsiano
Uganda, Kampala
Makerere University
Oguche, Stephen O.
Nigeria, Jos
University of Jos
Omede, Ogu
Nigeria, Abuja
Federal Ministry of Health
Omuemu, Casimir Erhunmwun
Nigeria, Benin
University of Benin
Opare-Sem, Ohene K.
Ghana, Kumasi
Kwame Nkrumah University of Science & Technology
Opio, Christopher Kenneth
China, Hong Kong
Kwong Wah Hospital
Örmeci, Necati
Turkey, Ankara
Ankara Üniversitesi
Papatheodoridis, George V.
Greece, Athens
School of Medicine
Pimenov, Nikolay N.
Russian Federation, Moscow
Central Research Institute of Epidemiology
Poustchi, Hossein
Iran, Tehran
Tehran University of Medical Sciences
Qureshi, Huma I.
Pakistan, Islamabad
Pakistan Medical Research Council
Ramji, Alnoor S.
Canada, Vancouver
The University of British Columbia
Razavi-Shearer, Kathryn
United States, Lafayette
Cda Foundation
Redae, Berhane
Ethiopia, Addis Ababa
Ethiopian Medical Association
Ethiopia, Addis Ababa
St. Paul‘s Hospital Millennium Medical College
Reésink, Hendrick W.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Ríos, Cielo Yaneth
Colombia, Bogota
Ministry of Health and Social Protection
Robbins, S. J.
United States, Lafayette
Cda Foundation
Roberts, Lewis Rowland
United States, Rochester
Mayo Clinic
Roberts, Stuart Keith
Australia, Melbourne
The Alfred
Australia, Clayton
Monash University
Safadi, Rifaat
Israel, Jerusalem
Hadassah University Medical Centre
Sagalova, Olga I.
Unknown Affiliation
Salupere, Riina
Estonia, Tartu
Tartu Ülikooli Kliinikum
Sanai, Faisal M.
Saudi Arabia, Riyadh
King Saud University
Saudi Arabia, Jeddah
King Abdulaziz Medical City - Jeddah
Sánchez Ávila, Juan Francisco
Mexico, Monterrey
Tecnológico de Monterrey
Saraswat, Vivek Anand
India, Lucknow
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Sarrazin, Christoph M.
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Germany, Wiesbaden
St. Josefs-hospital, Wiesbaden
Schmelzer, Jonathan D.
United States, Lafayette
Cda Foundation
Schréter, Ivan
Slovakia, Kosice
Pavol Jozef Šafárik University in Košice
Seguin-Devaux, Carole
Luxembourg, Strassen
Luxembourg Institute of Health
Shah, Samir R.
Unknown Affiliation
Sharara, Ala I.
Lebanon, Beirut
American University of Beirut
Sharma, Manik
Qatar, Doha
Hamad Medical Corporation
Shiha, Gamal Elsayed
Egypt, Cairo
Egyptian Liver Research Institute and Hospital
Sievert, William
Australia, Clayton
Monash University
Australia, Clayton
Monash Health
Star̈kel, Peter
Belgium, Louvain-la-neuve
Université Catholique de Louvain
Stedman, Catherine Ann Malcolm
New Zealand, Christchurch
Christchurch Hospital new Zealand
Sypsa, V. Anastasia
Greece, Athens
School of Medicine
Tan, Soeksiam
Malaysia, Kuala Lumpur
Selayang Hospital
Tanaka, Junko
Japan, Higashihiroshima
Hiroshima University
Tomasiewicz, Krzysztof
Poland, Lublin
Medical University of Lublin
van der Meer, Adriaan J.P.
Netherlands, Rotterdam
Erasmus Mc
Vella, Stefano
Italy, Rome
Istituto Superiore Di Sanita
Vince, Adriana
Croatia, Zagreb
University of Zagreb
Waheed, Yasir
Pakistan, Islamabad
Foundation University, Islamabad
Waked, I. A.
Egypt, Cairo
National Liver Institute
Walsh, Nick
United States, Washington, D.c.
Pan American Health Organization
Weis, Nina M.
Denmark, Copenhagen
Rigshospitalet
Denmark, Copenhagen
Københavns Universitet
Wong, Vincent Wai Sun
Hong Kong, Hong Kong
Chinese University of Hong Kong
Yaghi, César G.
Lebanon, Beirut
Université Saint-joseph de Beyrouth
Yang, Hwai I.
Taiwan, Nankang
Academia Sinica Taiwan
Yosry, Ayman
Egypt, Giza
Cairo University
Yuen, Man Fung
Hong Kong
Queen Mary Hospital Hong Kong
Yusuf, Muhammed Aasim
Pakistan, Lahore
Shaukat Khanum Memorial Cancer Hospital and Research Centre
Zeuzem, Stefan S.
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Razavi, Homie A.
United States, Lafayette
Cda Foundation
Statistics
Citations: 1,205
Authors: 179
Affiliations: 162
Identifiers
Doi:
10.1016/S2468-1253(18)30056-6
ISSN:
24681253
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Systematic review