Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC)
International Journal of Cancer, Volume 118, No. 3, Year 2006
Notification
URL copied to clipboard!
Description
Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 6.0 years of follow-up we identified 287 incident cases of RCC. Relative risks were calculated using Cox regression, stratified by age and study center and adjusted for smoking status, education, alcohol consumption, physical activity, menopausal status, and hormone replacement therapy use. Among women, an increased risk of RCC was conferred by body weight (relative risk [RR] in highest vs. lowest quintile = 2.13; 95% confidence interval [CI] = 1.16-3.90; p-trend = 0.003), body mass index (BMI) (RR = 2.25; 95% CI = 1.14-4.44; p-trend = 0.009), and waist (RR = 1.67; 95% CI = 0.94-2.98; p-trend = 0.003) and hip circumference (RR = 2.30; 95% CI = 1.22-4.34; p-trend = 0.01); however, waist and hip circumference were no longer significant after controlling for body weight. Among men, hip circumference (RR = 0.44; 95% CI = 0.20-0.98; p-trend = 0.03) was related significantly to decreased RCC risk only after accounting for body weight. Height was not related significantly to RCC risk. Our findings suggest that obesity is related to increased risk of RCC irrespective of fat distribution among women, whereas low hip circumference is related to increased RCC risk among men. Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases. © 2005 Wiley-Liss, Inc.
Authors & Co-Authors
Pischon, Tobias
Germany, Nuthetal
German Institute of Human Nutrition
Lahmann, Petra H.
Germany, Nuthetal
German Institute of Human Nutrition
Boeing, Heiner
Germany, Nuthetal
German Institute of Human Nutrition
Tjønneland, A. Marie
Denmark, Copenhagen
Kræftens Bekæmpelse
Halkjaer, Jytte
Denmark, Copenhagen
Kræftens Bekæmpelse
Overvad, Kim
Denmark, Aarhus
Aarhus Universitetshospital
Klipstein-Grobusch, Kerstin
Germany, Nuthetal
German Institute of Human Nutrition
Linseisen, Jakob P.
Germany, Heidelberg
German Cancer Research Center
Trichopoulou, Antonia D.
Greece, Athens
National and Kapodistrian University of Athens
Benetou, Vassiliki
Greece, Athens
National and Kapodistrian University of Athens
Trichopoulos, Dimitrios V.
Greece, Athens
National and Kapodistrian University of Athens
Sieri, Sabina
Italy, Milan
Fondazione Irccs Istituto Nazionale Dei Tumori, Milan
Palli, Domenico
Italy
Centro Per lo Studio e la Prevenzione Oncologica
Tumino, Rosario
Italy, Ragusa
Azienda Ospedaliera Civile M.p. Arezzo
Vineis, Paolo
United Kingdom, London
Imperial College London
Italy, Turin
Università Degli Studi Di Torino
Panico, Salvatore
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Monninkhof, Evelyn M.
Netherlands, Utrecht
University Medical Center Utrecht
Peeters, Petra H.M.
Netherlands, Utrecht
University Medical Center Utrecht
Bueno-de-Mesquita, H. B.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Buc̈hner, Frederike Leonie
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Ljungberg, Börje J.
Sweden, Umea
Umeå Universitet
Hallmans, Goran
Sweden, Umea
Umeå Universitet
Berglund, Göran L.
Sweden, Lund
Lunds Universitet
González Svatetz, Carlos A.
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Dorronsoro, Miren L.
Unknown Affiliation
Barricarte, Aurelio
Spain, Pamplona
Instituto de Salud Publica, Pamplona
Navarro, Carmen A.
Spain, Murcia
Health Council of Murcia
Martínez, Carmen
Spain, Granada
Escuela Andaluza Salud Publica
Quirõs, Josè Ramõn
Unknown Affiliation
Roddam, Andrew Wilfred
United Kingdom, Oxford
University of Oxford
Allen, Naomi E.
United Kingdom, Oxford
University of Oxford
Bingham, Sheila Anne
United Kingdom, Cambridge
Mrc Mitochondrial Biology Unit
Khaw, Kay Tee T.
United Kingdom, Cambridge
University of Cambridge
Kaaks, Rudolf J.
France, Lyon
Centre International de Recherche Sur le Cancer
Norat, Teresa
France, Lyon
Centre International de Recherche Sur le Cancer
Slimani, Nadia
France, Lyon
Centre International de Recherche Sur le Cancer
Riboli, Elio B.
France, Lyon
Centre International de Recherche Sur le Cancer
Statistics
Citations: 179
Authors: 37
Affiliations: 23
Identifiers
Doi:
10.1002/ijc.21398
ISSN:
10970215
Research Areas
Cancer
Food Security
Noncommunicable Diseases
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female