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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis and in vivo evaluation of the biodistribution of a 18F-labeled conjugate gold-nanoparticle-peptide with potential biomedical application
Bioconjugate Chemistry, Volume 23, No. 3, Year 2012
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Description
Gold nanoparticles (AuNPs) have been extensively used in biological applications because of their biocompatibility, size, and ease of characterization, as well as an extensive knowledge of their surface chemistry. These features make AuNPs readily exploitable for biomedical applications, including drug delivery and novel diagnostic and therapeutic approaches. In a previous work, we studied ex vivo distribution of the conjugate C(AuNP)-LPFFD for its potential uses in the treatment of Alzheimer's disease. In this study, we covalently labeled the conjugate with [18F]-fluorobenzoate to study the in vivo distribution of the AuNP by positron emission tomography (PET). After intravenous administration in rat, the highest concentration of the radiolabeled conjugate was found in the bladder and urine with a lower proportion in the intestine, demonstrating progressive accumulation compatible with biliary excretion of the conjugate. The conjugate also accumulated in the liver and spleen. PET imaging allowed us to study the in vivo biodistribution of the AuNPs in a noninvasive and sensitive way using a reduced number of animals. Our results show that AuNPs can be covalently and radioactively labeled for PET biodistribution studies. © 2012 American Chemical Society.
Authors & Co-Authors
Guerrero, Simon
Chile, Santiago
Universidad de Chile
Herance, José Raúl
Spain, Barcelona
Parc de Recerca Biomèdica de Barcelona
Mena, Juan F.
Chile, Santiago
Universidad de Chile
Acosta, Gerardo A.
Spain, Barcelona
Irb Barcelona - Institute for Research in Biomedicine
Spain, Madrid
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina
Alberício, Fernando
Spain, Barcelona
Irb Barcelona - Institute for Research in Biomedicine
Spain, Madrid
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina
Spain, Barcelona
Universitat de Barcelona
Kogan, Marcelo Javier
Chile, Santiago
Universidad de Chile
Statistics
Citations: 105
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1021/bc200362a
ISSN:
10431802
Research Areas
Environmental