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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Preparation and drug-delivery potential of metronidazole-loaded PELA tri-block co-polymeric electrospun membranes
Journal of Biomaterials Science, Polymer Edition, Volume 20, No. 9, Year 2009
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Description
The aim of this study was to investigate the potential of poly(ethylene glycol-co-lactide) (PELA tri-block with a segmental sequence of PLA-PEG-PLA) electrospun membranes as drug-delivery vehicles using metronidazole as a model drug. PELA membranes with smooth surfaces and no bead defects were electrospun from polymer solutions containing 20% (w/v) PELA in 8:2 N,N-dimethyl formamide (DMF)/acetone. The morphology of the drug-loaded electrospun membranes was influenced by electrospinning parameters such as the flow rate and voltages during preparation. Metronidazole could be released from the electrospun membranes and was characterized by an initial burst effect. Higher voltages led to faster release rates, while an increase in the flow rate decreased the drug release. The incorporation of metronidazole into the electrospun membranes decreased their surface hydrophilicity. The amount of drug released from the electrospun membranes was effective in inhibiting microbial growth. Cell adhesion on the PELA membranes with or without drug was less than that on the homo-polymeric PDLLA membranes. Proliferation of L929 mouse fibroblasts on the PELA membranes was observed. This study confirms the potential of metronidazole-loaded PELA biodegradable electrospun membranes for optimizing the clinical therapy of post-surgical adhesions and infections. © 2009 Koninklijke Brill NV, Leiden.
Authors & Co-Authors
Yang, Dejuan
China, Chengdu
Sichuan University
China, Chengdu
Chengdu Institute of Organic Chemistry Chinese Academy of Sciences
Xiong, Chengdong
China, Chengdu
Chengdu Institute of Organic Chemistry Chinese Academy of Sciences
Govender, Thirumala
South Africa, Durban
University of Kwazulu-natal
Wang, Yuzhong
China, Chengdu
Sichuan University
Statistics
Citations: 22
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1163/156856209X453024
ISSN:
09205063
e-ISSN:
15685624
Research Areas
Health System And Policy