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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Comparison of Elastography, Serum Marker Scores, and Histology for the Assessment of Liver Fibrosis in Hepatitis B Virus (HBV)-Infected Patients in Burkina Faso
American Journal of Tropical Medicine and Hygiene, Volume 82, No. 3, Year 2010
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Description
Liver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis B. In Burkina Faso, liver biopsy (LB) remains the "gold standard" method for this purpose. Access to treatment might be simpler if reliable alternative techniques for LF evaluation were available. The hepatitis B virus (HBV)-infected patients who underwent LB was invited to have liver stiffness measurement (Fibroscan) and serum marker assays. Fifty-nine patients were enrolled. The performance of each technique for distinguishing F0F1 from F2F3F4 was compared. The area under receiver operating characteristic (AUROC) curves was 0.61, 0.71, 0.79, 0.82, and 0.87 for the aspartate transaminase to platelet ratio index (APRI), Fib-4, Fibrotest, Fibrometre, and Fibroscan. Elastometric thresholds were identified for significant fibrosis and cirrhosis. Combined use of Fibroscan and a serum marker could avoid 80% of biopsies. This study shows that the results of alternative methods concord with those of histology in HBV-infected patients in Burkina Faso. These alternative techniques could help physicians to identify patients requiring treatment. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Bonnard, P.
France, Paris
Hôpital Tenon
Sombié, Roger Arsène
Burkina Faso
Chu Yalgado Ouédraogo
Lescure, François Xavier
France, Paris
Hôpital Tenon
Bougouma, Alain
Burkina Faso
Chu Yalgado Ouédraogo
Guiard-Schmid, J. B.
France, Paris
Hôpital Tenon
Poynard, T.
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Calès, Paul
France, Angers
Chu Angers
Housset, Chantal
France, Paris
Hôpital Tenon
Callard, Patrice
France, Paris
Hôpital Tenon
Le-Pendeven, Catherine
France, Paris
Hôpital Tenon
Drabo, Joseph Youssouf
Burkina Faso, Ouagadougou
Centre Hospitalier Universitaire Yalgado Ouedraogo
Carrat, Fabrice
France, Paris
Inserm
Pialoux, Gilles
France, Paris
Hôpital Tenon
Statistics
Citations: 74
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.4269/ajtmh.2010.09-0088
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Burkina Faso